妊娠期高血压危险因素病例对照研究

The risk factors of hypertensive disorder in pregnancy:A case-control study

目的研究妊娠期高血压发生的危险因素，为预防和控制其发生提供参考。方法回顾性选取我院住院并诊断为妊娠期高血压的孕产妇作为病例组，选择同期住院的健康孕产妇作为对照组，分析影响妊娠期高血压发生的影响因素。结果单因素分析比较发现，年龄≥35岁（OR=2．67，95％CI：1．56～3．73）、孕前BMI≥28kg／m2（OR=1．79，95％CI：1．18～2．48）、流产次数≥2次（OR：2．08，95％CI：1．16～2．43）、高血压家族史（OR=1．45，95％CI：1．64～3．72）是妊娠高血压发生的危险因素；多因素Logistic回归模型分析发现，年龄≥35岁（OR=2．107，95％CI：1．398-3．861）、孕前BMI≥28kg／m2（OR=1．769，95％CI：1．318～2．392）和高血压家族史（OR=1．626，95％CI：1．215～2．284）为妊娠期高血压发生的危险因素。结论高龄、孕期超重、高血压家族史是妊娠高血压发生的危险因素，针对重点人群应该加强控制，预防妊娠高血压的发生。

Objective To study the risk factor of hypertensive disorder in pregnancy and support the basic information for prevent and control the disease. Methods The patients who were the hypertensive disorder in pregnancy were the case group, and the healthy patients in the same time were chosen as the control group. The information was analyzed to study the risk factors. Results Univariate analysis and comparison found that age ≥ 35 years （OR=2.67,95%CI： 1.56- 3.73）, pre-pregnancy BM1 ≥ 28 kg/m2 （0R=1.79,95%CI： 1.18-2.48）,≥ 2 times the number of abortions （0R=2.08,95% CI： 1.16-2.43） ,family history of hypertension （OR=1.45,95%CI： 1.64-3.72）were risk factors for pregnancy-induced hypertension; multivariate Logistic regression analysis showed that age ≥ 35 years （0R=2.107,95%CI： 1.398-3.861）, pre-pregnaney BMI ≥ 28 kg/m2（OR=1.769,95%Cl： 1.318-2.392）, and family history of hypertension （OR=1.626,95% CI： 1.215-2.284） were risk factors for hypertension in pregnancy. Conclusion Age, pregnancy with overweight, family history of hypertension are risk factors for hypertension in pregnancy,it is impartment to control the risk factors of the focus patients and prevent the hypertension in pregnancy.