危重早产儿血胃泌素水平动态变化的研究

Research on blood gastrin levels in preterm infants

目的:探讨危重早产儿血胃泌素(GAS)水平的变化。方法:用放射免疫法分别测定30例危重早产儿(观察组,胎龄<37w,体重>1500g)和20例早产儿(对照组,胎龄<37w,体重>1500g)生后72h、7天血GAS水平。结果:(1)观察组72hGAS水平明显低于对照组(P<0.05),2组7天GAS水平比较无统计学意义;(2)观察组GAS水平的变化与其危重评分正相关。结论:危重早产儿血GAS水平发生明显变化,该变化与其危重度密切相关,提示在早产儿,对危重症的发生、发展中可能参与应激过程的调控,血GAS动态变化是否作为反映早产儿感染发生、发展及消化功能状态的敏感临床监测指标,值得关注。

[ Objective] To explore the serum gastrin （GAS） levels in severe preterm infants. [Method] 30 severe preterm in- fants （gestational age 〈 37week, weight〉 1500g）were enrolled in study group. At the same time, 20 preterm infants were in- cluded as the control group （ age 〈 37week, weight 〉 1500g）. The concentration of serum GAS were measured by radio - im- munoassy at 72 hours and 7 days after their birth. [ Result] 1. The blood GAS level at 72 hours in the study group was lower （P 〈 0.05） than the control group. However, there was no statistic difference（P 〉 0.05）after 7 days. 2. Significant correla- tions were found between the GAS levels and the critical levels. [Conelusion] Compared with control group, Significant changes are seen in GAS levels of severe preterm infants. The GAS leves in preterm infant is related to severity GAS may be in- volved in stress process regulation of GAS when the infection develops. The dynamic GAS levels may be a sensitive indexe in reflecting the inflection situation in preterm infants.