益气活血化痰方治疗稳定型冠心病临床观察

Clinical Effective Observation of Yiqihuoxuehuatan Decoction on Patients with Stable Coronary Artery Disease

目的观察益气活血化痰方治疗稳定型冠心病的临床疗效。方法将100例患者随机分为对照组和治疗组各50例。对照组应用硝酸异山梨酯缓释胶囊、酒石酸美托洛尔、拜阿司匹林(1年内行经皮冠状动脉内介入术患者加用氯吡格雷)、辛伐他汀片、培哚普利,剂量根据患者个体情况增减,疗程1个月。治疗组在西药治疗基础上加用益气活血化痰中药,每日1剂。治疗期3个月。观察两组心绞痛发作情况(心绞痛发作频率、持续时间、硝酸甘油用量),中医证候改善情况和超敏C反应蛋白(hs-CRP)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、三酰甘油(TG)浓度。结果治疗组中医证候总有效率明显高于对照组(P<0.05)。两组治疗前后心绞痛发作频率、心绞痛持续时间和硝酸甘油用量均有非常显著变化(P<0.01),组间比较差异无统计学意义(P>0.05)。治疗组治疗前后hs-CRP有显著改变(P<0.05);治疗组治疗前后LDL-C、HDL-C和TG均有非常显著改善(P<0.01)。与对照组比较,治疗组HDL-C和TG均有显著性改善(P<0.05)。结论中西医结合治疗稳定型冠心病可显著减少心绞痛发作频率,降低硝酸甘油的服用量,改善患者的临床证候,同时改善患者的血脂水平。

Objective： To observe the clinical effect of Yiqihuoxuehuatan Decoction on patients with Stable Coronary Artery Disease.Methods： 100 patients were randomized into the control group（treated with standard western medicine,50 cases） and the treatment group（treated with standard western medicine and Yiqihuoxuehuatan Decoction,50 cases）,matched by age and gender.The period was 3 months.Angina pectoris attacks（frequency,duration and doses of nitroglycerin）,improvement rate of symptom of TCM,high-sensitivity c-reactive protein（HS-CRP）,LDL-C（low density lipoprotern-cholesterol）,HDL-C（high density lipoprotern-cholesterol） and TG（triglyceride） were observed and compared.Results： Total effective rate in the treatment group was higher than control group（P 0.05）;The frequency,duration of angina and dose of nitroglycerin were very significant decrease after than before treatment in the two groups（P 0.01）;The frequency and dose of nitroglycerin were more in the treatment than in the control before treatment（P 0.01）;there were no difference between the two groups after treatment（P 0.05）.HS-CRP were significant decreased after than before treatment in the treatment（P 0.05）;LDL-C,HDL-C and TG were very significant decrease after than before treatment in the treatment（P 0.01）;HDL-C and TG were significant decrease in the treatment than in the control after treatment（P 0.05）.Conclusion： Treatment of stable coronary artery disease with integrated traditional Chinese and western medicine could significantly reduce frequency of angina attack,decrease dose of nitroglycerin,improve clinical symptoms and meanwhile level of blood lipid.