通腑泻肺方对AECOPD痰热壅肺证的疗效分析及对炎症介质的影响

Analysis about the Effect of Tongfuxiefei Method on AECOPD with the Syndrome of Phlegm-heat Obstructing Lung and the influence on inflammatory mediators

目的观察通腑泻肺法对慢性阻塞性疾病急性加重期(AECOPD)痰热壅肺证的疗效以及炎症介质的影响,探讨AECOPD肺肠同治的生物学基础。方法将60例患者随机分为两组,即治疗组(西医综合治疗加通腑泻肺方口服)和对照组(单纯西医综合治疗)。肿瘤坏死因子(TNF-α)、血浆白细胞介素(IL-1β、IL-6、IL-8):均采用酶联免疫法(ELISA)测定,分别在治疗前和治疗后10 d进行测定。结果治疗组总有效率均高于对照组;治疗后治疗组IL-8、TNF-α较对照组明显下降;与治疗前比较,治疗组IL-8和TNF-α均明显改善(P均<0.05)。结论通腑泻肺中药联合西药综合治疗能够提高疗效,缓解临床症状;通腑泻肺方的干预治疗可以降低AECOPD炎症介质IL-8及TNF-α水平。

Objective： To observe the effect of Tongfuxiefei Method on AECOPD with the Syndrome of Phlegmheat Obstructing Lung and the influence on inflammatory mediators,and to inquire the biological basis of AECOPD lung and intestine Tongzhi.Methods： Sixty patients were divided into two groups.The control group were treated with antibiotics while the treatment group were treated with both Tongfuxiefei Decoction and antibiotics.TNF-α,IL-1β,IL-6,IL-8.ELISA assay were taken to measure respectively in 10 days before and after the treatment.Results： The total effective rate of the treatment group was obviously superior to that of the control group（P 0.05）.IL-8,TNF-αof both groups were improved,while the treatment group was more significant（P 0.05）.Conclusion： The curative effects of Tongfuxiefei Decoction in combination with antibiotics are superior to that of the control group on AECOPD.Intervention by Tongfuxiefei Decoction can decrease AECOPD IL-8 and TNF-α levels of inflammatory mediators.