肾结石并尿路感染215例病原菌分布及耐药性分析

Analysis of pathogenic bacteria and drug-resistance in 215 patients with urinary tract infection combined with renal calculi

目的探讨肾结石合并尿路感染病原菌分布以及常用抗生素的药物敏感性。 方法对2010~2011年我院因肾结石合并尿路感染住院患者215例行尿液细菌培养,对培养结果阳性46例患者进行病原菌及对主要抗生素的耐药情况进行分析。结果尿培养病原菌分布依次为大肠埃希菌（58.7%）、铜绿假单孢菌（10.9%）、肠球菌（8.7%）等；对阿米卡星的敏感率为77.8%；头孢哌酮耐药率为62.9%。结论目前肾结石并尿路感染最常见的病原菌仍为大肠埃希菌，对头孢类抗生素耐药率逐渐增高，治疗上应以病原菌培养和药物敏感结果为依据，合理选择抗生素。

ObjectiveTo investigate the pathogenic bacteria and drugresistance in urinary tract infection with renal calculi. MethodsUrine samples of 215 patients with urinary tract infection combined with renal calculi were cultured. Pathogenic bacteria and drugresistance of 46 patients with positive results were analyzed. ResultsThe pathogenic bacteria included Escherichia coli （58.7%）, pseudomonas aeruginosa （10.9%） and enterococcus faecalis （8.7%）. The drugsensitivity to amikacin was 77.8%; the drugresistance to cefoperazone was 62.9%. Conclusions The major pathogenic bacterium of urinary tract infection with renal calculi was Escherichia coli. As the drugresistance to cephalosporin antibiotics was increasing, proper antibiotics should be selected based on the results of drug sensitivity test.