心肌生物标志物的应用前景与挑战

Application prospects and challenges of cardiac biomarkers

敏感而特异的心肌生物标志物对心血管疾病早期、正确的诊断和治疗至关重要.肌钙蛋白（超敏肌钙蛋白）、肌红蛋白、心型脂肪酸结合蛋白、缺血修饰白蛋白以及B型利钠肽和N端B型利钠肽原（BNP/NT-proBNP）的应用,大大提高了心血管疾病的早期诊断率,并在危险分层及预后方面有重要意义,但仍需进一步完善.同时具备高特异度、高灵敏度及检测方便等特点的心肌生物标志物仍然是未来研究的方向.

Cardiac biomarkers of sensitive and specific are very important to the early diagnosis of cardiovascular diseases, such as cardiac troponin （high sensitivity ）, myoglobin, heart-fatty acid-binding protein, ischemia modified albumin, B-type natriuretic peptide and N-terminal-pro-B-type natriuretic peptide. They also play an important role in risk stratification and prognosis evaluation, but improvement is still needed. Biomarker of high sensitivity and specificity, convenient detection control is still required in clinical application.