全氟化碳液体短期术后填塞治疗巨大视网膜裂孔(英文)

Short term postoperative tamponade using perfluorocarbon liquid for treatment of giant retinal tears

目的:探讨全氟化碳液体短期术后填塞治疗视网膜脱离伴巨大视网膜裂孔的有效性和安全性。方法:检索从1998-01/2010-12在单一的医疗中心治疗患者的病历数据。比较应用和没有应用全氟化碳液体的患者的视网膜复位成功率,视力预后及术后并发症。结果:术后,治疗组22眼(21例),对照组14眼(14例)视网膜均附着。两组的最终附着率分别为81.8%和42.9%(P<0.05)。治疗组4眼(18.2%),对照组7眼(50%)发展为重症增生性玻璃体视网膜病变和持续性视网膜脱离。治疗组73.3%,对照组26.7%患者的视力为6/12或更高(P<0.05)。治疗组50.0%,对照组14.3%患者视力提升;治疗组22.7%,对照组57.1%患者视力下降(P=0.054)。结论:视网膜脱离伴巨大视网膜裂孔使用全氟化碳液体作为短期术后填塞是安全的。全氟化碳液体在预防增生性玻璃体视网膜病变方面有效。

To investigate the efficacy and safety of perfluorocarbon liquid （ PFCL as a short term postoperative tamponade for treating retinal detachment associated with giant retinal tears. METHODS： Data was retrieved from the medical charts of patients who underwent vitrectomy from January 1998 to December 2010 at a single medical center. Success rates of retinal reattachment, visual outcome, and postoperative complications were compared between procedures with and without PFCL. RESULTS： At the end of surgery, all retinas were attached in the 22 eyes （21 patients） treated with PFCL and in the 14 eyes （14 patients） not treated with PFCL as temporary tamponade. Final reattachment rates were 81.8% and 42. 9%, respectively （ P〈 0. 05）. Four eyes （18.2%） in the study group compared to 7 eyes （50%） in the control group developed severe proliferative vitreoretinopathy with persistent retinal detachment. Visual acuity was 6/12 or better in 73. 3% of the study group and 26.7% of the control group, P〈0.05. Visual acuity improved in 50.0% of patients in the study group and 14.3% in the control group. Visual acuity worsened in 22.7% of the patients in the study group and 57.1% in the control group （P=0. 054）. CONCLUSION： Perfluorocarbon liquid appears safe and effective as a short term postoperative tamponade in the management of retinal detachment from giant retinal tears and in the prevention of proliferative vitreoretinopathy.