摘要
Bcl-2是从滤泡上B细胞内分离出来的一个原癌基因,与细胞的凋亡密切相关。近年来,其广泛应用于中枢神经的损伤修复实验中,尤其表现在眼科领域的视神经损伤的研究中,可以抑制细胞凋亡,延长细胞生命期限,不能促进细胞增殖。然而在其他一些实验中,Bcl-2的抗凋亡作用却不明显,对于某些基因突变所致的凋亡无阻止作用,针对视神经的保护作用不明显。
Bcl-2 is a proto-oncogene isolated from follicular B cells, and it is closely related to cell apoptosis. In recent years, it has been widely used in experiments to repair central nervous injury, especially the optic nerve injury. In some cases, it is found that Bcl-2 can inhibit cell apoptosis, prolong cell life span, but can not promote cell proliferation. In other cases, it can not prevent apoptosis caused by certain genetic mutations and thus cannot protect the optic nerve.
出处
《国际眼科杂志》
CAS
2013年第10期1998-2000,共3页
International Eye Science
基金
国家自然科学地区基金(No.31160206)~~
关键词
视神经损伤
抗凋亡
运用
optic nerve injury
antiapoptosis
application
