真菌性角膜炎病原学及药物性分析

Etiology and drug resistance analysis on fungal keratitis

目的:探究并分析2011/2012年真菌性角膜炎患者角膜边缘溃疡培养结果病原菌分布和耐药性情况。方法:采集2011-01-01/2012-12-31在我院眼科收治的68例真菌性角膜炎患者角膜边缘溃疡,将其送真菌分离培养、鉴定和药物敏感试验,总结真菌性角膜炎患者角膜边缘溃疡培养结果及药物敏感试验结果。结果:在68份送检角膜边缘溃疡中,检出50株真菌菌株以镰刀菌属为最多,对纳他霉素、氟康唑、两性霉素和伊曲康唑耐药率分别为26%,46%,54%,60%。结论:真菌菌株以镰刀菌属为最多,真菌性角膜炎对两性霉素和伊曲康唑耐药性更高,对纳他霉素耐药率较低。

AIM.- To investigate and analyze corneal edge ulcer training results, pathogenic bacteria distribution and drug resistance status of fungal keratitis. METHODS： Corneal edge ulcer of 68 fungal keratitis patients who were treated in our hospital from January 1, 2011 to December 31, 2012 was collected. They were sent to isolate culture, identification and drug sensitive test. The culture and drug sensitive test results, and pathological changes of corneal tissue were summarized. RESULTS.Fifty strains of fungi strains were checked out from 68 corneal edge ulcer, most of them were sickle bacteria genus. The resistant rate of natamycin, fluconazole, amphotericin and itraconazole was 26%, 46%, 54% and 60%, respectively. CONCLUSION： The most pathogenic bacteria were sickle bacteria genera, the resistance of amphotericin and itraconazole is higher, while that of itraconazole is lower.