糖皮质激素眼液在流行性角结膜炎治疗中的应用

Clinical observation of glucocorticoid eye drops in the treatment of epidemic keratoconjunctivitis

目的:探讨糖皮质激素眼液在流行性角结膜炎(epidemic kerato conjunctivitis,EKC)免疫反应期的治疗效果。方法:选取临床并发结膜伪膜或(和)角膜上皮下浸润的EKC患者206例359眼,治疗组在常规抗病毒治疗基础上加用糖皮质激素眼液,对照组仅做常规抗病毒治疗,定期复查观察结膜伪膜及角膜上皮下浸润的治疗疗效,并监测眼压变化。结果:治疗组加用糖皮质激素眼液后结膜伪膜治疗有效率为91.4%,对照组有效率为56.9%,差异有统计学意义(P<0.05);治疗组中角膜上皮下浸润治疗有效率为90.8%,对照组有效率为61.8%,差异有统计学意义(P<0.05)。结论:在EKC患者免疫反应期加用糖皮质激素眼液对伪膜形成及角膜上皮下浸润是一种有效的、安全的治疗方法,可以缩短病程、避免角膜云翳的产生。

AIM. To explore the effect of glucocorticoid eye drops in the treatment of epidemic keratoconjunctivitis （EKC） during the immune reaction period. METHODS：Totally, 206 EKC patients （359 eyes） with conjunctival pseudomembranous or （ and ） the subepithelial corneal infiltrates were selected. The treatment group used glucocorticoid eyes drops in conventional antiviral treatment and the control group only underwent the conventional antiviral therapy. Treatment effects were periodically reviewed and intraocular pressure was monitored. RESULTS： The total effective rates in conjunctive pseudomembranous were 91. 4% and 56. 9%; and the total effective rates in subepithelial corneal infiltrates were 90.8% and 61.8%. The difference was statistically significant （P〈0.05）. CONCLUSION. Using glucocorticoid eye drops during the immune reaction period of EKC is a safe and effective, which can prevent pseudomembranous formed and promote the absorbed of the subepithelial corneal infiltrates.