食物不耐受与变应性鼻炎、哮喘的相关性研究

Correlative study on food intolerance,allergic rhinitis and asthma

目的:探讨血清食物特异性IgG抗体检测在变应性鼻炎、哮喘中的临床意义,为变应性鼻炎、哮喘的病因诊断及防治提供参考依据。方法:采用ELISA方法检测28例变应性鼻炎、28例变应性哮喘、9例变应性鼻炎合并哮喘患者血清中14种食物特异性IgG抗体。结果:65例患者中,食物特异性IgG总阳性率为66.2%,各组IgG阳性检出率无显著性差异(P>0.05)。3组患者的主要食物致敏源谱系既有相同性亦有一定差异性,其中螃蟹、鸡蛋和牛奶是所有疾病组中共有的检出阳性率最高的3种食物;患者中检出阳性率较高(阳性率<10%)的食物还有大米、玉米、小麦、虾和西红柿;食物不耐受患者中,对1种食物不耐受者所占比例最多,其次为2种食物不耐受者,3种以上食物不耐受者所占比例较小。结论:变应性鼻炎、哮喘患者食物不耐受发生率较高,食物不耐受与变应性鼻炎、哮喘具有密切相关性。食物特异性IgG抗体检测对变应性鼻炎、哮喘的病因诊断、治疗和预防具有重要意义。

Objective： To investigate the clinical significance of food - specific IgG antibodies in serum in patients with allergic rhinitis and asthma, and provide guiding instructions for diagnosis, treatment and prevention of the two diseases. Methods： Fourteen food - specific IgG antibodies in the serum of 65 patients were determined by ELISA assay. Results：The total positive rate of food - specific IgG was 66.2 %. No significant difference was observed among groups （P 〉 0.05）. The positive rates of crab, egg and milk were the highest among all groups. In addition, the main allergic foods with higher positive rates were rice, corn, wheat, shrimp and tomato, respec- tively. Conclusion： A higher positive rate of food - specific IgG is found in patients with allergic rhinitis and asth- ma. There is a close relationship among food intolerance, allergic rhinitis and asthma. Detection of food - specific IgG antibody in serum is of importance for diagnosis, treatment and prevention in allergic rhinitis and asthma.