白芍总苷和维生素B2治疗复发性阿弗他溃疡的疗效评定

The clinical evaluation and comparison of total glycosides of paeony and vitamin B 2 in the treatment of re- current aphthous ulcer

目的:观察与比较白芍总苷和维生素B2在治疗复发性阿弗他溃疡(recurrent aphthous ulcer,RAU)中的临床疗效及不良反应。方法:将100例RAU患者随机分为2组,治疗组50例采用白芍总苷治疗,对照组50例采用维生素B2治疗,2组疗程均为6个月。根据中华口腔医学会黏膜病专业委员会的"RAU疗效评价试行标准"进行疗效评价。结果:2组患者在治疗期内的总间歇期均延长,溃疡总数目均减少。2组比较,白芍总苷组疗效优于维生素B2组(P<0.05);白芍总苷对RAU间歇期的延长优于维生素B2(t=4.89,P<0.01);对RAU溃疡数目的减少也优于维生素B2(t'=7.87,P<0.01)。白芍总苷组9例发生轻度不良反应,维生素B2组未观察到不良反应。结论:白芍总苷治疗RAU具有较好的疗效不良反应轻微。

Objective： To observe and compare the effects and adverse reactions of total glycosides of paeony （TGP） and vitamin B2 （VB2） in the treatment of recurrent aphthous ulcer（RAU）. Methods： 100 RAU patients were divided into two groups. 50 patients were treated by TGP, and another 50 by VB2. The treatment was continued for 6 months. The effects were evaluated according to the trial standard of Chinese Stomatological Association. Results： The interval of RAU increased and ulcer number decreased in the 2 groups during treatment, TGP w^ts more effective than VB2 （ P 〈 0.05 ）. In TGP group RAU interval increased more than in VB2 group（ t = 4.89, P 〈 O. 01 ） and RAU ulcer number decreased more （ t＇ = 7.87, P 〈 0.01 ）. Minor adverse reation was observed in 9 cases in TGP group and 0 in VB2 group. Conclusion： TGP is effective in the treatment of RAU without sever adverse reactions.