肥胖伴隐匿性高血压患者血清中期因子水平分析

Analysis of Serum Midkine Level in Patients with Masked Hypertension and Obesity

目的探讨肥胖伴隐匿性高血压(masked hypertension,MH)患者血清中期因子(midkine,MK)水平及临床意义。方法选择诊所血压(CBP)正常的肥胖者100例和体质量正常的健康体检者50例作为对照组,均行24h动态血压监测(ABPM)。按日间血压监测结果,肥胖组被分为肥胖MH组(诊所血压正常,日间动态血压高于正常值)41例和单纯肥胖组59例。采用酶联免疫吸附法检测检测外周血MK含量。对比分析两组血清MK水平及其与日间血压的关系。结果 (1)MK比较:与单纯肥胖组和对照组比较,肥胖MH组血清MK明显升高(P均<0.05);单纯肥胖组与对照组比较差异无统计学意义。(2)血压比较:肥胖MH组的dSBP、dDBP均明显高于单纯肥胖组和对照组(P均<0.01)。Pearson相关分析显示,肥胖MH组血清MK水平与dSBP、dDBP均呈正相关(P均<0.01)。结论肥胖患者MH与血清MK水平有关,MK可能参与了肥胖患者高血压的发生发展过程。

Objective To investigate the level and clinical significance of serum midkine in patients with masked hypertension and obesity.Methods Based on the results of ambulatory blood pressure monitoring （ABPM） and body mass index（BMI）,150 subjects with normal clinical blood pressure were divided into three groups,obesity with masked hypertension group（n =41）,single obesity group （n =59） and healthy control group（n =50）.The level of serum M K was detected by elisa method.The level of three groups＇serum M K was compared and the relationship between serum MK level and daytime blood pressure was comparatively analysed.Results （1） MK compare,the serum MK level of obesity with masked hypertension group was significantly higher than that of obesity group （P 〈 0.05）.there was no significant difference in serum MK between single obesity group and healthy control group.（2） Blood pressure compare,the dSBP and dDBP of besity with masked hypertension group was significantly higher than that of the other two groups （P 〈 0.01）.Pearson correlation analysis indicated that the serum MK level of obesity with masked hypertension group was positively correlated with the level of dSBP （P 〈 0.01） and dDBP （P 〈 0.01）.Conclusion The level of serum MK may be associated with masked hypertension and obesity.MK may be involved with the occurrence and development of masked hypertension in obesity patients.