超声波探测系统模拟肠内容物感知神经的作用

Simulation of intestinal content sensory nerves with ultrasonic detection system

背景:现有的人工肛门括约肌不能感知肠管内是否有肠内容物及肠内容物的状态,既往对肠内容物信号的研究未对不同结肠部位不同状态肠内容物信号进行研究。目的:比较对射式超声波信号探测系统测量新西兰兔不同大肠部位不同状态肠内容物电压信号的差异。方法:选用20只健康新西兰兔,每只兔按近结肠远端、远结肠远端、直肠远端3个部位进行分组,每组选取5个固体大便颗粒处作为测量点,用超声波信号探测系统分别测量每个测量点内固体、流体、气体、肠管空虚4种状态大便的电压信号。结果与结论:在直肠部位,除了直肠内的固体和气体比较差异无显著性意义外,其余不同状态比较差异均有显著性意义(P=0);在远结肠和近结肠内的不同状态多重比较差异均有显著性意义(P=0)。对固体和流体而言,直肠、远结肠、近结肠之间差异有显著性意义(P=0),多重比较差异亦均有显著性意义(P=0);对气体和空虚状态而言,直肠、远结肠、近结肠之间差异无显著性意义。不同的大肠部位和不同状态肠内容物之间存在交互效应(P=0)。提示对射式超声波信号探测系统具有分辨不同肠内容物"人工肠内容物感觉神经"的作用,用超声波探测不同状态肠内容物可为研究"人工肠内容物感知神经"提供一种有效方法。

BACKGROUND： The existed artificial anal sphincter cannot sense whether there are intestinal contents in the bowel and the state of intestinal contents, and the previous studies on the intestinal content signal did not included the different parts of colon and the signals of different intestinal content status. OBJECTIVE： To compare the differences of ultrasound signals of different intestinal content status in different parts of New Zealand rabbits detected with transmission-type ultrasonic signal detection system. METHODS： Twenty healthy New Zealand rabbits ware used; the rabbits were divided into groups according to distal part of proximal colon, distal colon and distal rectum. Five positions of solid stool particles were selected randomly as the detection point in each group. The voltage signals of stool were measured under solid, fluid, gaseous, and deflation status of the lumen. RESULTS AND CONCLUSION： In rectum, there were no significant differences in voltage signals between solid and gaseous conditions, while there were significant differences between fluid and deflation conditions（P=-0.000）. Multiple comparison showed there were significant differences between four conditions in distal part of proximal colon and distal colon （P=0）. There were significant differences in voltage singles between rectum, distal colon and proximal colon under solid and fluid conditions （P=0）. Multiple comparison showed there were significant differences in any part of large bowel for solid and fluid status （P=-0）. There were no significant differences in voltage singles between rectum, distal colon and proximal colon under gaseous and deflation conditions. There was interactive effect of intestinal contents between three parts of large bowel under the four conditions （P=O.000） Transmission-type ultrasonic detection system can distinguish artificial intestinal contents sensory nerves of variousintestinal contents. And the application of ultrasonic detection system to detect the intestinal contents under different conditions can provide a new effective method for the research on artificial intestinal content sensory nerves.