骨软骨组织库来源同种异体骨软骨移植物的临床应用

Clinical applications of allogeneic osteochondral grafts from osteochondral tissue bank

背景:关节软骨全层损伤的治疗一直是骨科和运动医学科处理的难题。同种异体骨软骨移植可提供有活性和具有生物力学性能的透明软骨,修复全层关节软骨缺损。关节软骨组织库提供的同种异体骨软骨移植物来源充足,在膝关节软骨缺损的治疗中前景可观。目的:总结关节软骨组织库提供的同种异体骨软骨移植物的取材、保存、质量控制及临床应用方面的研究进展。方法:由第一作者用计算机检索PubMed数据库和中国期刊全文数据库2013年1月前发表的文章,检索词分别为"tissue bank,knee,articular cartilage,preservation,transplatation"和"组织库,膝,关节软骨,保存,移植",语言分别设定为英文和中文。总结骨软骨组织库取材、保存方法、质量控制及骨软骨移植物在膝关节软骨缺损治疗的临床应用进展。结果与结论:共检索到194篇文章,按纳入和排除标准对文献进行筛选,共纳入19篇文章。结果表明,同种异体骨软骨移植是治疗膝关节软骨缺损的有效方法,建立骨软骨组织库可为膝关节软骨缺损的治疗提供安全、有活性的组织,目前骨软骨组织库还处于起始阶段。

BACKGROUND： Full-thickness articular cartilage injury is notoriously difficult to be treated in the fields of orthopedics and sports medicine. AIIogeneic bone and cartilage transplantation can offer a transparent cartilage with biological activity and biomechanical properties to repair full-thickness articular cartilage defects. AIIogeneic osteochondral grafts from osteochondral tissue bank are adequate, and have a good prospect in the treatment of articular cartilage defects. OBJECTIVE： To summarize the drawn materials, preservation, quality control and clinical monitoring of allogeneic osteochondral grafts supported by the osteochondral tissue bank. METHODS： The first author searched PubMed and CNKI for the relevant articles published before 2013 using the key words of ＂tissue bank, knee, articular cartilage, preservation, transplantation＂ in English and Chinese respectively. After retrieval, we summarized the drawn materials, preservation, quality control and clinical monitoring of allogeneic osteochondral grafts supported by the osteochondral tissue bank. RESULTS AND CONCLUSION： Nineteen of 194 rebieved articles were enrolled according to inclusive and exclusive criteria. The results show that aUogeneic bone and cartilage transplantation is an effective method for the treatment of articular cartilage defects, and the establishment of the osteochondrat tissue bank can provide safe and active tissues for the treatment of articular cartilage defects. Now, the osteochondral tissue bank is still in the initial stage.