骨保护素基因G1181C多态性与绝经妇女骨密度的Meta分析

Association between osteoprotegerin gene G1181C polymorphism and bone mineral density in postmenopausal women: A Meta-analysis

背景:遗传学研究显示骨保护素基因G1181C多态性与绝经妇女骨密度可能存在关系,但研究结论存在一定差异。目的:采用Meta分析方法研究骨保护素基因G1181C(rs2073618)多态性与绝经后妇女骨密度的关系。方法:检索PubMed、Embase、CNKI、万方数据库中关于骨保护素基因rs2073618位点G1181C多态性与骨密度关系的观察性研究。以标准化均数差为效应指标,并根据异质性检验结果选择随机效应模型或固定效应模型计算标准化均数差。结果与结论:纳入9篇文献,测定椎骨骨密度8 799人,测定股骨颈骨密度9 365人。分析结果显示,携带G等位基因的绝经妇女椎体骨密度比携带C等位基因者低,高加索人群亚组分析显示相同结果。此外,高加索人群的亚组分析显示,携带GG基因型的绝经妇女股骨颈骨密度低于携带GC和CC基因型者。说明骨保护素基因G1181C多态性与绝经后妇女骨密度存在相关性,G等位基因是发生骨密度降低的危险因子。

BACKGROUND： Genetic studies have shown that there may be association between osteoprotegerin gene G1181C polymorphism and bone mineral density in postmenopausal women, but there are some differences in the conclusions. OBJECTIVE： To study the association between osteoprotegerin gene G1181C polymorphism and bone mineral density in postmenopausal women through Meta-analysis. METHODS： The PubMed database, Embase database, CNKI database and Wanfang database were searched for the observational studies about the association between osteoprotegerin gene G1181C polYmorphism and bone mineral density in postmenopausal women. The standardized mean difference was considered as the effect indicator and calculated with random or fixed effect models according to the significance of heterogeneity. RESULTS AND CONCLUSION： A total of 9 articles were included with a total of 8 799 and 9 365 participants for which vertebral and spine bone mineral density had been measured, respectively. The analysis results showed that the bone mineral density of the postmenopausal women with the G allele of G1181C was significantly lower than that of the postmenopausal Women with the C allele. Similar results were obtained in Caucasian population subgroup analysis. The Caucasian population subgroup analysis showed that the bone mineral density of the postmenopausal women with GG genotype of G 1181C was lower than that of the postmenopausal women with GC and CC genotype. The results indicate that there is association between osteoprotegerin gene G1181C Ibolymorphism and bone mineral density in postmen0pausal women, and G allele is a risk factor for lower bone mineral density.