腹腔镜后联合诺雷德综合治疗卵巢囊肿的临床疗效分析

Clinical efficacy of laparoscopy combined with zoladex treatment for ovarian cysts

目的:探究腹腔镜术后联用诺雷德治疗卵巢巧克力囊肿的治疗效果。方法:选取我院2005-2010年间我院妇产科收治的192例卵巢巧克力囊肿患者为研究对象,诺雷德组96例患者行腹腔镜下卵巢囊肿剔除,术后加用诺雷德治疗;孕三烯酮组96例术后予孕三烯酮治疗。监测患者术后激素水平变化并观察两组患者疗效、卵巢囊肿复发率、妊娠率及副作用的情况。结果:诺雷德组E_2水平明显低于孕三烯酮组(P<0.05);孕三烯酮组治疗有效率为65.22%,明显低于诺雷德组的80.43%(P<0.05);孕三烯酮组复发率达41.30%,明显高于诺雷德21.74%(P<0.05);孕三烯酮组妊娠率44.44%低于诺雷德组的62.32%(P<0.05)。结论:腹腔镜术后联用诺雷德治疗卵巢巧克力囊肿,术后雌激素控制在低水平且较稳定,停药后可恢复;卵巢囊肿复发率低,受孕率高,疗效好,副作用少,安全可靠,推荐临床使用。

Objective To explore the therapeutic effect of laparoscopy combined with zoladex treatment for ovarian chocolate cysts. Methods 192 patients with ovarian chocolate cysts treated in our hospital between 2009- 2012 were divided into 2 groups; all patients received laparoscopic excision of ovarian cyst; and after the surgery, 96 patients in zoladex group received zoladex treatment, and 96 patients in gestrinone group received gestrinone treatment. The postoperative changes of hormone levels, efficacy, recurrence rate of ovarian cysts, pregnancy rates and side effects wre observed. Results E2 level in zoladex group was significantly lower than that in gestrinone group （P 〈 0.05）. The effective rates, recurrence rates and pregnancy rates in gestrinone group and zoladex group were 65.22% vs. 80.43% （P 〈 0.05）, 41.30% vs. 21.74% （P 〈 0.05）, and 44.44% vs. 62.32% （P 〈 0.05）. Conclusion After laparoscopy combined with zoladex treatment for ovarian chocolate cysts, the postoperative estrogen was controlled at a low level and was more stable; the recurrence rate was low, the pregnancy rate was high, the side effects were few, and was safe and reliable.