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我院2011-2012年奥美拉唑使用情况及处方分析 被引量:4

Analysis of Usage and Prescription of Omeprazole in Our Hospital
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摘要 目的:提高奥美拉唑合理用药水平。方法:从医院信息系统调取2011年和2012年奥美拉唑的制剂使用数据,从使用人次、使用量和使用金额等方面进行分析。并随机抽查10 000张奥美拉唑处方,统计、分析不合理处方情况。结果:该医院2012年奥美拉唑的使用人次较2011年有所下降,降幅为8.6%,使用金额的下降幅度为5.55%。注射剂型在使用人次和使用金额上都有所下降,而口服奥美拉唑剂型都出现了较大幅度的上升。抽查的10 000张处方中,有1 752张为不合理处方,包括无指征用药963张(55.0%),不合理联用药物789张(45.0%)。结论:该院奥美拉唑临床应用存在过度预防现象,并且不合理用药较多,尚需加强对医师的教育和管理,以促进奥美拉唑的合理使用。 OBJECTIVE:To improve rational use of omeprazole in our hospital.METHODS:The utilization of omeprazole in our hospital in 2011 and 2012 were collected from our hospital information system and analyzed in respect of the number of patients,quantity and amount,etc.10 000 omeprazole prescriptions were randomly collected,and the unreasonable prescriptions were analyzed statistically.RESULTS:Compared with 2011,The number of patients treated with omeprazole in our hospital in 2012 was decreased to some extent,decreasing by 8.6%;the amount of omeprazole was decreased by 5.55%.The number of patients and amount of injection were declined to some extent,while those of oral dosage form were increased greatly.Among 10 000 prescriptions,there were 1 752 irrational prescriptions,including 963 prescriptions without indication(55.0%),789 prescriptions of irrational drug combination(45.0%).CONCLUSIONS:The excessive preventive phenomenon exists in clinical application of omeprazole in our hospital.The use of omeprazole is irrational mostly.In the future,we need to strengthen education and management in order to promote the rational use of omeprazole.
出处 《中国药房》 CAS CSCD 2013年第36期3439-3441,共3页 China Pharmacy
关键词 奥美拉唑 处方分析 合理用药 过度预防 Omeprazole Analysis of prescriptions Rational drug use Excessive prevention
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  • 1Forgacs I, Loganayagam A. Overprescribing proton pump inhibitors[J]. BMJ, 2008,336 (7 634) : 2.
  • 2王砚,向道春,刘东.长江流域6城市233家医院2007-2009年质子泵抑制剂利用分析[J].中国药房,2011,22(42):3948-3950. 被引量:6
  • 3Lodato F, Azzaroli F, Turco L, et al. Adverse effects of proton pump inhibitors[J]. Best Pract Res Clin Gastroen- terol, 2010,24(2) : 193.
  • 4George C J, Korc B, Ross JS. Appropriate proton pump inhibitor use among older adults: a retrospective chart re- view[J]. Am J Geriatr Pharmacother, 2008,6 (5) : 249.
  • 5Niklasson A, Bajor A, Bergendal L, et al. Overuse of ac- id suppressive therapy in hospitalised patients with pu|mo- nary diseases[J]. Respir Med, 2003,97 (10):1 143.
  • 6van Vliet EP, Otten H J, Rudolphus A, et al. Inappropri- ate prescription of proton pump inhibitors on two pulmo- nary medicine wards[J]. Eur J Gastroenterol Hepatol, 2008,20 (7) : 608.
  • 7APhA. ASHP therapeutic guidelines on stress ulcer proph- ylaxis. ASHP commission on therapeutics and approved by the ASHP board of directors on November 14, 1998 [J]. Am J Health Syst Pharm , 1999,56(4) : 347.
  • 8Lanza FL, Chan FK, Quigley EM. Guidelines for preven- tion of NSAID-related ulcer complications[J]. Am J Gas- troenterol, 2009,104(3) :728.
  • 9许国铭,萧树东,李兆申,黄庭,孙永华,卢亦成,杨兴易,湛先保,赵继宗,王集生.应激性溃疡防治建议[J].中华医学杂志,2002,82(14):1000-1001. 被引量:296

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  • 1陈新谦,金有豫,汤光.新编药物学[M].17版.北京:人民卫生出版社,2011:3465.
  • 2卫生部.医院处方点评管理规范:试行[s].2010-01-01.
  • 3Lodato F, Azzaroli F, Mazzella N, et al. Adverse effects of proton pump inhibitors [ J ]. Best Pract Res Clin Gastroenterol, 2010,24 (2) :193 -201.
  • 4Hagiwara T, Mukaisho K, Nakayama T, et al. Long-term proton pump inhibitor admin istrationworsens atrophic corpus gastritis and promotes adenocarcinoma development in Mongolian gerbils infec- ted with Helicobacter pylori [ J ]. Gut,2011,60 (5) :624 - 630.
  • 5Fashner J, Gitu AC. Common gastrointestinal symptoms:risks of long - term proton pump inhibitor therapy [ J ]. FP Essent, 2013, 413:29 - 39.
  • 6Xu H, Ren D. Lysosomal physiology[ J. Annu Rev Physiol,2015, 77:57 - 80.
  • 7Liu W, Baker SS, Trinidad J, et al. Inhibition of lysosomal enzyme i activities by proton pump inhibitors [ J ]. J Gastroenterol, 2013,48 (12) : 1343 - 1352.
  • 8Seydoux E, Rothen-Rutishanser B, Nita IN, et al. Size - dependent accumulation of particles inlysosomes modulates dendritic cell function through impaired antigen degradation[ J]. Int J Nanomed- icine ,2014,9:3885 - 3902.
  • 9Mindell JA. Lysosomal acidification mechanisms [ J . Annu Rev Physiol,2012,74:69 - 86.
  • 10Morgan A J, Platt FM, Lloyd-Evans E, et al. Molecular mechanisms of endolysosomal Ca2 signalling in health and disease [ J ]. Bio- chem J,2011,439:349 - 374.

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