核因子κB信号通路在肺癌中的作用

Role of NF-κB signaling pathway in lung cancer

核因子κB（nuclear factor-κB,NF-κB）是调控多种基因表达的核转录因子,其活化失调不仅与各种炎症性疾病有关,而且在肺癌的发生、发展、转移及治疗中也发挥着重要的作用.近年来研究发现,NF-κB可能是抗癌药物治疗的靶点,为肺癌等恶性肿瘤的治疗提供了新思路.

Nuclear factor-kB （NF-kB） is a nuclear transcription factor that regulates expression of diverse genes . Its activation disproportion is not only involved in a variety of inflammatory diseases, but also plays an important role in the development, progress, metastasis, and treatment of lung cancer . Recently, some studies have found that NF-kB may be a target for anti-cancer drugs, providing a new idea for the treatment of lung cancer and other malignant tumors.