美托洛尔用于急性心梗早期溶栓治疗临床观察

Clinical efficacy of metoprolol for early thrombolysis in treatment of acute myocardial infarction

目的探讨美托洛尔用于急性心梗早期溶栓治疗临床效果。方法选取我院收治急性心梗患者50例,采用随机数字表法分为对照组和观察组;其中对照组患者25例,给予常规抗心梗药物治疗;观察组患者25例,在对照组治疗基础上,加用美托洛尔治疗;比较两组患者心源性猝死率、心源性休克率、再梗死率、死亡率及治疗前后QRS积分等。结果观察组患者心源性猝死率、再梗死率及死亡率均明显低于对照组,组间比较差异显著(P<0.05);而两组患者心源性休克率组间比较无显著差异(P>0.05);两组患者治疗后QRS评分均明显低于治疗前,且观察组患者下降程度均明显优于对照组,组间比较无显著差异(P<0.05)。结论美托洛尔用于急性心梗早期溶栓治疗可有效降低再梗死及死亡风险,改善预后。

Objective To investigate the clinical efficacy of metoprolol for early thrombolysis in the treatment of acute myocardial infarction. Methods Fifty patients with acute myocardial infarction who were admitted to our hospital were divided into control group （n=25） and observation group （n=25） using a random number table. The control group received conventional medication for myocardial infarction, while the observation group received metoprolol in addition to the treatment for control group. The incidence of sudden cardiac death, incidence of cardiogenic shock, recurrence rate of infarction, mortality rate, and QRS scores before and after treatment were compared between the two groups. Results The observation group had significantly lower incidence of sudden cardiac death, recurrence rate of infarction, and mortality rate than the control group （P〈0.05）. There was no significant difference in incidence of cardiogenic shock between the two groups （P〉0.05）. Both groups showed significant decreases in QRS scores after treatment, and the observation group had a significantly higher decrease than the control group （P〈0.05）. Conclusion Metoprolol can effectively reduce the recurrence of infarction and mortality risk and improve prognosis when used for early thrombolysis in the treatment of acute myocardial infarction.