尼莫地平肠溶微囊的制备及体外释放度考察

Study on the Preparation and Release Activity of Enteric Dissolving Nimodipine Microcapsules

目的:优化尼莫地平肠溶微囊的制备工艺并对其体外释放度进行考察。方法:以纤维醋法酯(CAP)为载体材料,利用单凝聚法,通过正交试验设计,考察囊材与囊芯比、溶解CAP所需磷酸氢二钠pH值及量、span-80量及凝聚剂用量、成囊温度等因素对微囊包封率及载药量的影响,初步筛选出最佳处方工艺条件。此外,还建立了紫外分光光度法测定微囊的载药量与包封率,考查其体外释放度。结果:所得微囊外观圆整,测得平均包封率为80.4%,平均载药量为41.7%。结论:该制备方法简单易行,所制得的微囊肠溶效果理想。

Objective：To study on the preparation method and release activity of enteric microeapsules for nimodipine. Methods： The enteric dissolving microcapsules of NMD were manufactured by the methods of simple coacervation method using CAP as coating material. This paper mainly studied on the release properties of NMD in vitro. The ratio of drug to CAP, the amount of flocculating agent and span--80, and the pH value of the CAP effected to the accumulation release percentage of the microcapsules were studied. Results：The microcapsules were regular in shape and the drug loading and entrapment efficiency were 80.4 %and 41.7 % respee tively. ConcLusion ： The microeapsules show significant enteric release character.