肺炎支原体感染与儿童哮喘的关系研究

目的研究儿童哮喘与肺炎支原体感染之间的关系。方法选择2010年10月-2011年10儿科治疗的哮喘患儿188例、肺炎患儿98例,另选择健康儿童20例作为对照组,分别对3组患儿的血清肺炎支原体IgM(MP-IgM)抗体使用颗粒凝集法进行检测,对哮喘患者血清总IgE进行测定。结果支气管哮喘患儿的MP-IgM阳性率(48.97%)明显高于肺炎患儿的MP-IgM阳性率(36.91%),差异具有统计学意义(P<0.05)。两组患者的MP-IgM阳性率均高于对照组(5.97%),差异具有统计学意义(P<0.05)。其中学龄儿童的MP-IgM阳性率明显高于其它年龄的患儿阳性率(P<0.05)。MP-IgM阳性的支气管患儿血清总IgE水平明显高于MP-IgM阴性的支气管患儿的血清总IgE(P<0.05)。结论儿童哮喘的发病率与肺炎支原体感染有密切关系,尤其学龄儿童肺炎支原体MP-IgM阳性更高,应该加强关注。

Objective To study the relationship between asthma and Mycoplasma pneumoniae infection in children. Methods Select 388 Cases of pediatric asthma in our hospital during October, 2010 - October,2011, treatment of pneumonia in 298 cases, the other 40 cases of healthy children as control group, respectively in three groups of children with mycoplasma pneumonia IgM （ MP-IgM ） antibodies using particle agglutination assay, determination of total serum IgE asthma. Results The positive rate of MP-IgM in children with bronchial asthma （ 48.97% ） the positive rate of MP-IgM was significantly higher than that in children with pneumonia （36.91%）, the difference was comparable （P〈0.05）. Compared with the control group, the positive rate of MP-IgM in the patients of the two groups were higher than those in the control group （5.97%）, the difference was comparable （P〈0.05）. The positive rate of MP-IgM children is significantly higher than the positive rate of children of other ages （P〈0.05）. Total serum IgE in children with bronchial bronchial MP-IgM positive serum total IgE levels were significantly higher than that of MP-IgM negative （P〈0.05）. Conclusion The incidence of asthma in children with Mycoplasma pneumoniae infection has close relationship, especially children mycoplasma pneumonia positive of MP-IgM high, should strengthen the attention.