甲酸钠法合成鸟嘌呤的研究

Study on synthesis and analysis of guanine by sodium formate

目的研究合成精制鸟嘌呤的方法。方法以2,4,5-三氨基-6-羟基嘧啶硫酸盐和甲酸钠为原料,在3 atm压力和甲酸催化下,通过回流反应得到粗品鸟嘌呤,用盐酸酸化后,再用氨水处理得到精制鸟嘌呤。结果当物质的量配比(2,4,5-三氨基-6-羟基嘧啶硫酸盐∶甲酸)为1∶1.5,反应时间为8 h,以铁粉作还原剂时,得率较高。结论甲酸钠法工艺简单,操作容易控制,产品收率较高且反应时间短,易于实现工业化生产,是合成鸟嘌呤的良好方法。

Objective To study the method of synthesis of guanine.Methods Guanine was synthesized by 2,4,5-3 amino-6-pyrimidine sulphate and sodium formate under the conditions of 3 atm and formic acid as the catalyst through acidification by hydrochloric acid,treated by ammonia water.The reaction yield was strongly dependent on the reaction factors such as raw materials matching,reaction time,and so on.Results The raw material radio （2,4,5-3 amino-6- pyrimidine sulphate：sodium formate） of 1：1.5 and 8 h reaction time was the optimum technical condition.Conclusion It is the best method to synthesize guanine with simple technology,high Percent recovery and short reaction time.