Ki67、P16在子宫颈上皮内瘤变中的应用

Application of Ki67,P16 in cervical intraepithelial neoplasia

目的探讨Ki67、P16在子宫颈上皮内瘤变(CIN)中的诊断分级效果。方法选取本院50例子宫颈上皮内瘤变Ⅰ型(CINⅠ)、50例高度鳞状上皮内病变(其中,CINIⅠ20例,CINⅢ30例)、50例慢性宫颈炎患者,观察患者Ki67、P16的表达效果。结果 Ki67表达阳性细胞在宫颈鳞状上皮中的位置分布与CIN级别间存在显著相关性。P16表达水平在CINⅠ、CINⅡ、CINⅢ级间差异有统计学意义,表达水平与CIN级别呈正相关。结论 Ki67、P16对子宫颈上皮内瘤变诊断和分级有一定辅助作用。

Objective To discuss the effect of diagnosing classification of Ki67 and P16 in cervical intraepithelial neoplasia. Methods 50 patients with cervical intraepithelial neoplasia type Ⅰ （CIN Ⅰ ）,50 patients with high-grade squamous intraepithelial lesions （among them,CIN Ⅱ 20 cases,CIN Ⅲ 30 cases）,50 patients with chronic cervicitis were selected treated in our hospital,then the expression of Ki67,P16 effect was observed. Results A significant correlation between the distribution of positive cells of Ki67 expression in cervical squamous epithelium with CIN class （P〈0.05）. The expression level of P16 had significant differences between CINⅠ、CINⅡ、CINⅢ ,expression level are in positively correlated with CIN levels. Conclusion Ki67 and P16 have certain auxiliary effect on the diagnose and classify of cervical intraepithelial neoplasia.