医用镁合金生物降解行为研究进展

Research Progress on Biodegradation Behavior of Biomedical Magnesium Alloy

镁及镁合金作为新型医用植入材料,具有优异的力学性能和可降解性,正吸引着越来越多研究者的关注。相较于体内实验及临床研究,体外实验更能快速、直观地得到结论,并且反馈到体内实验及临床研究中。综合评述了医用镁合金在模拟生理环境及动物模体内生物降解行为的最新研究进展,详细介绍了医用镁合金在模拟体液环境、蛋白质环境和动物机体环境中的腐蚀行为的主要研究成果。

As a new type of medical implant materials, magnesium and magnesium alloys, which possess excellent mechanical properties and biodegradability, are attracting more and more researchers＇ attentions. Compared, with in vivo and animal/human studies, in vitro experiments are more convenient and can provide quick and reasonable feedback on the efficacy, and the results are typically used to complement in vivo and clinical studies. A review has been presented focusing on the latest research progresses on biodegradation behavior of magnesium alloys in simulated physiological environment and animal model （in vivo）. Meanwhile, a detailed description has also been provided for the main research achievements about the corrosion behavior of magnesium alloys in simulated body fluid, in protein environment, and in vivo.