紫杉醇联合三维适形放疗治疗局部晚期非小细胞肺癌的临床价值

The Clinical Efficacy of Paclitaxel Combined with Three Dimensional Conformal Radiation Therapy on Local Advanced Non-small Cell Lung Cancer

目的分析临床应用紫杉醇联合三维适形放疗(3D-CRT)治疗局部晚期非小细胞肺癌的应用价值。方法选取2009年11月至2011年3月我院收治的106例局部晚期非小细胞肺癌患者,按随机数字表法随机分为对照组和观察组各53例,对照组给予三维适形放疗,观察组在对照组治疗的基础上给予紫杉醇联合治疗,分析两组患者治疗后的临床疗效。结果治疗完成后观察组PD患者较对照组明显减少,而治疗有效率较对照组明显升高(P<0.05);两组患者不良反应发生率比较无明显差异(P>0.05),无统计学意义。结论临床应用紫杉醇联合三维适形放疗治疗局部晚期非小细胞肺癌能获得良好的治疗效果,且不会产生明显的不良反应,可作为治疗局部晚期非小细胞肺癌的首选方法。

Objective To evaluate the clinical efficacy of Paclitaxel combined with three dimensional conformal radiation therapy （3D-CRT） on local advanced non-small cell lung cancer. Methods 106 cases of local advanced non-small cell lung cancer, treated in our hospital over November, 2009 to March, 2011, were randomly assigned to control group or observation group according to random number table. Each group was consisted of 53 cases respectively. 3D-CRT alone were performed on each case in control group, meanwhile paclitaxel combined with 3D-CRT were applied on patients in observation group. The therapeutic effects were analyzed in both two groups after treatment. Results The Progression disease （PD） and overall response rate （ORR） were signiifcantly improved in observation group than in control group （P〈0.05）.The difference of occurrence rate of adverse reaction were not signiifcant between the two groups （P〉0.05）. Conclusion Paclitaxel combined with 3D-CRT had favorable clinical efifcacy and less adverse reactions. This regime had the potential to become the ifrst line treatment on local advanced non-small cell lung cancer.