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依那普利叶酸治疗H型高血压的疗效 被引量:9

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摘要 目的对依那普利叶酸片治疗H型高血压的临床疗效进行分析探讨。方法选取H型高血压患者60例,随机分为两组。观察组30例患者,给予依那普利叶酸片进行治疗;对照组30例患者,给予依那普利片进行治疗。结果两组患者经过1个疗程的治疗后,观察组30例患者,总有效率93.4%;对照组30例患者,总有效率66.7%。观察组的总有效率优于对照组,两种治疗方法有显著性差异,有统计学意义,有可比性(P<0.05)。两组患者治疗4周及12周后,舒张压与收缩压较治疗前均下降,且观察组患者血压下降值较对照组明显。观察组患者的不良事件发生率少于对照组,两种治疗方法有显著性差异,有统计学意义,有可比性(P<0.05)。结论依那普利叶酸治疗H型高血压有很好的临床疗效,有一定的临床应用价值。
出处 《中国医药指南》 2013年第25期123-124,共2页 Guide of China Medicine
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  • 1Stankovic S,Majkic SN.Genetic aspects of ischemic stroke:coagulation,homocysteine,and lipoprotein metabolism as potential risk factors[J].Crit Rev Clin Lab Sci,2010,47(2):72-123.
  • 2Graham I M,Daly L E,Refsum H M,et al.Plasma homocysteine as a risk factor for vascular dasease[J].JAMA,1997,277(22):1775-1781..
  • 3WANG X,QIN X,DEMIRASH,et al.Efficacy of folic acid supplem entation in stroke prevention ameta-analysis[J].Lancet,2007,369(9576):1876-1882.
  • 4ALBERT CM,COOK NR,GAZIANO M,et al.Effect of folic acid and B vitam ins on risk of cardiovascular evevts and total mortality among women at high risk for cardiovascular diease[J].JAMA,2008,299(17):2027-2036.
  • 5Buccianti G,Baragetti I,Bamonti F,et al.Plasma homocysteine levels and cardiovascular mortality in patients with end-stage renal disease[J].Nephrol,2004,17(3):405-410.
  • 6Ghorbanihaghjo A,Javadzadeh A,Argani H,et al.Lipoprotein(a),homocysteine,and retinal arteriosclerosis[J].Mol Vis,2008,14(9):1692-1697.
  • 7Wang X, Qin X, Demirtas H, et al Efficacy of fofic acid supplementation in stroke prevention [J]. a meta-analysis Lancet, 2007, 369: 1876-1882.
  • 8Chia S, Wilson R, Ludlam CA, et al. Endothelial dys-function in patients with recent myocardial infarction and hyperhomocys- teinaemia: effects of vitamin supplementa-tion [J]. Clin Sci (Lond), 2005, 108 (1): 65-72.
  • 9Chia S, Wilson R, Ludlam CA, et al. Endothelial dys-function in patients with recent myocardial infarction and hyperhomocys-teinaemia: effects of vitamin supplementa-tion [J]. Clin Sci (Lond), 2005, 108 (1): 65-72.
  • 10Muda P, Kampus P, Zilmer M, et al. Effect of antihy-pertensive treatment with candesartan or amlodipine on glutathione and its re- dox status, homocysteine and vita- min concentrations in patients with essential hyperten-sion [J]. J Hypertens, 2005, 23 (1): 105.

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  • 1魏新旺.依那普利叶酸治疗H型高血压的临床疗效[J].求医问药(下半月),2013(10):300-300. 被引量:4
  • 2李建平,霍勇,刘平,秦献辉,关德明,葛均波,胡健,王燕妮,张馥敏,毛广运,徐希平.马来酸依那普利叶酸片降压、降同型半胱氨酸的疗效和安全性[J].北京大学学报(医学版),2007,39(6):614-618. 被引量:386
  • 3Hao L, Ma J, Zhu J, et al. High prevalence of hyperhomocysteinemia in Chi- nese adults is associated with low folate, vitamin B-12, and vitamin B-6 status [J]. J Nutr, 2007, 137(2) :407-413.
  • 4Toffoli G, de Mattia E. Pharmacogenetic relevance of MTHFR polymorphisms [J]. Pharmacogenomics, 2008, 9(9):1195-1206.
  • 5Almawi WY, Ameen G, Tamim H, et al. Factor VG1691A, prothrombin G20210A, and methylenetetrahydrofolate reductase [ MTHF] C677Tgene poly- morphism in angiographically documented coronary artery disease[ J ]. J Thromb Thrombolysis ,2004,17 (3) : 199-205.
  • 6Goldstein LB, Bushnell CD, Adams RJ, et al. Guidelines for the primary pre- vention of stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association [ J ]. Stroke, 2011,42 ( 2 ) : 517 - 584.
  • 7Steed MM, Tyagi SC. Mechanisms of cardiovascular remodeling in hyperhomo- cysteinemia[J]. Antioxid Redox Signal, 2011, 15(7) :1927-1943.
  • 8Zhao D, Liu J, Wang W, et al. Epidemiological transition of stroke in China: twenty-one-year observational study from the Sino-MONICA-Beijing Project[ J ]. Stroke,2008,39(6) :1668-1674.
  • 9Towfighi A, Markovic D, Ovbiagele B. Pronounced association of elevated ser- um homocysteine with stroke in subgroups of individuals: a nationwide study [J]. J Neurol Sci, 2010,298(1-2) :153-157.
  • 10Boushey C J, Beresford SA, Omenn GS, et al. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes[J]. JAMA, 1995,274(13) :1049-1057.

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