三维适形放疗治疗晚期非小细胞肺癌的临床疗效观察

Clinical Effect Observation of Three-dimensional Conformal Radiotherapy in Treatment of Advanced Non-small Cell Lung Cancer

目的探讨三维适形放疗治疗晚期非小细胞肺癌的临床疗效。方法将我院2010年1月至2012年6月间收治的92例晚期非小细胞肺癌患者随机分为常规放射治疗组(对照组)和三维适形放射治疗组(观察组),每组各46例,观察两组患者的近期疗效及毒副反应。结果观察组患者的临床疗效总有效率为76.1%,显著高于对照组患者的54.3%,组间差异有统计学意义(P<0.05)。观察组患者治疗后毒副反应发生率为28.3%,显著低于对照组患者的63.0%,组间差异有统计学意义(P<0.05)。结论采用三维适形放疗治疗晚期非小细胞肺癌临床疗效好,毒副反应发生率低,值得临床进一步推广使用。

Objective To investigate the clinical effect of three dimensional conformal radiotherapy in treatment of advanced non-small cell lung cancer. Methods 92 cases of advanced non-small cell lung cancer in our hospital from 2010 January to 2012 June were randomly divided into routine therapy group （control group） and three-dimensional conformal radiation therapy group （observation group）, 46 cases in each group, observed the clinical effect and toxicity of patients in two groups. Results The total effective rate of patients in observation group was 76.1%, signiifcantly higher than that in control group （54.3%）, there was signiifcant difference between two groups （P〈0.05）. Patients in the observation group, adverse reaction rate was 28.3%, signiifcantly lower than that in control group（63%）, there was signiifcant difference between two groups （P〈0.05）. Conclusion Taking three-dimensional conformal radiotherapy for advanced non-small cell lung cancer has good clinical effect, and adverse reaction rate is low, it is worthy of further clinical application.