摘要
目的比较氯氮平口腔崩解片与氯氮平普通片治疗精神分裂症的疗效及安全性。方法将68例精神分裂症患者随机分为氯氮平口腔崩解片组34例和氯氮平普通片组34例。分别给予氯氮平口腔崩解片和氯氮平普通片治疗8周。分别于治疗前及治疗2、4、6、8周采用阳性与阴性症状量表(PANSS)评定疗效,用不良反应量表(TESS)评定不良反应。结果两组疗效差异无显著性(P>0.05),氯氮平口腔崩解片不良反应显著少于氯氮平普通片。结论氯氮平口腔崩解片和氯氮平普通片对精神分裂症疗效相当,不良反应小,明显改善患者生活质量。
Objective To compare the efficacy and safety of clozapine orally disintegrating tablets and clozapine in the treatment of schizophrenia. Methods There were34 schizophrenia patients in study group treated with clozapine orally disintegrating tablets and34 schizophrenia patients in contyol group with clozapine for the treatment of 8 weeks. The efficacy was assessed with the positive and negative symptoms scale（PANSS）and TESS was used to evaluate the side effects before and ai%r treatment for. 2.4.6.8 weeks. Restults No significant difference was found in the efficacy between two groups, but the side effects were significantly less in clozapine orally disintegrating tablets group than in clozapine group. Conclusion Clozapine orally disintegrating tablets and clozapine are similarly effective and safe in the treatment of schizophrenia with improving the patients, ouality of life and mild side effects.
出处
《中国医药指南》
2013年第25期478-479,共2页
Guide of China Medicine
