2010年和2011年西安市大骨节病普查结果分析

An analysis of the census result of Kaschin-Beck disease in Xi＇an City in 2010 and 2011

目的掌握西安市大骨节病病区人群的病情变化及各年龄段的患病情况，为大骨节病制订针对性的防治决策提供科学依据。方法2010年和2011年，对西安市所有的大骨节病病区村7岁以上居民进行临床普查，统计Ⅰ、Ⅱ、Ⅲ度和不同年龄段大骨节检出率。结果共检查98561人，查出大骨节病现症患者7971人，检出率为8．09％。其中Ⅰ度5272人，检出率为5．35％；11度2259人，检出率为2．29％；111度440人，检出率为0．45％。随着年龄的增加，大骨节病的检出率逐渐升高，26岁以下年龄段无现症患者，36岁以上检出的现症患者占所有检出患者的99．46％（7928／7971）。结论西安市大骨节病病情平稳，现症患者以36岁以上人群为主，今后应针对成人大骨节病的治疗和药物的开发进行研究与探索。

Objective To master the prevalence trend of Kaschin-Beck disease and the situation of the disease in all age groups of the whole populations in Xi＇an Kaschin-Beck disease endemic areas, and to provide a scientific basis for development of targeted prevention measures and for decision-making. Methods All residents lived in the Kaschin-Beck disease endemic areas over the aged of 7 were clinically examined. The detection rate of grade Ⅰ、Ⅱ and Ⅲ Kaschin-Beck disease and prevalence of Kaschin-Beek disease by ages were calculated. Results A total of 98 561 persons were examined and 7971 patients were found, and the detection rate was 8.09%. The number of patient with grade Ⅰ、Ⅱ and Ⅲ Kaschin-Beck disease was 5272, 2259 and 440, respectively, and the detection rate was 5.35%, 2.29% and 0.45%, respectively. With increasing age, the detection rate of Kaschin-Beck disease was gradually increased. There were no patients below the age of 26 and patients over the age of 36 were accounted for 99.46% （7928/7971） of all patients. Conclusions Kaschin-Beek disease is in stable condition in Xi＇an. All patients are over the age of 36. Future research should be focused on drug development for adult patients with Kashin-Beck disease.