2011年甘肃省大骨节病病区儿童发硒含量检测结果分析

Analysis of selenium content in hair samples of children in Kaschin-Beck Disease areas in Gansu Province

目的比较甘肃省大骨节病病区儿童与非病区儿童发硒含量差异，为大骨节病防治提供实证数据。方法2011年选择甘肃省陇南、庆阳、定西3个市的大骨节病病区作为监测点，同时选择天水市农村和兰州市区的非病区作为对照点，分别采集6—12岁儿童发样，进行发硒含量测定。样品采用湿消化法处理，使用氢化物发生一原子荧光光谱法进行测定。结果甘肃省大骨节病病区共收集儿童发样254份，非病区儿童发样102份。陇南、庆阳、定西3个市的儿童发硒含量分别为[（0．22±0．07）、（0．22±0．00）、（0．20±0．07）mg／kg]，高于非病区的天水市和兰州市儿童发硒含量[（0．32±0．08）、（0．42±0．11）mg／kg]。比较各采样点儿童发硒最大值与最小值发现，病区儿童发硒范围相对较窄（0．08-0．46mg／kg），最小值、最大值均低于非病区（0．15-0．51mg／kg）。有51．1％（182／356）的儿童发硒含量〈0．25mg／kg，处于硒营养缺乏状态。另外，硒营养状况男生高于女生，但总体比较，差异无统计学意义。结论甘肃大骨节病病区儿童硒营养水平整体偏低，补硒还需长期坚持和多样化。

Objective To compare selenium content in hair samples of children in Kashin-Beck Disease （KBD） areas and control areas, and to provide academic data for KBD control and prevention. Methods In 2011, Longnan, Qingyang, Dingxi City of KDB areas in Gansu Provines were selected as survey point, meanwhile, colleagues of Tianshui City and Lanzhou City were selected as control. Hair samples of children aged between 6 and 12 years were taken from each survey point to determine the hair selenium. After using the nitric- perchlorie mixed acid to digest the sample, the concentrations of selenium were determined by hydride generator atomic fluorescence spectrometry. Results Two hundred and fifty-four samples from KBD areas and 102 samples from control areas were collected. The hair selenium of KBD areas[ （0.22±0.07）, （0.22±0.00）, （0.20±0.07） mg/kg], were higher than the control areas [ （0.32±0.08）, （0.42±0.11 ）mg/kg ]. After comparation of selenium content in every sampling point, we found the range of children＇s selenium content was relatively narrow in KBD areas （0.08 - 0.46 mg/kg）. The minimum value and the maximum value in KBD areas were lower than that of control areas （0.15 - 0.51 mg/kg）. A totle of 51.1% （182/356） of children was seriously lack of selenium, the hair selenium content was 〈 0.25 mg/kg. It was also found that Se content was not significantly different between boys and girls. Conclusions Children＇s selenium is deficient in KBD areas in Gansu. It is important to ensure salt supplement with selenium for a long period of time and through other ways to increase Selenium intake to control KBD.