弥散加权ADC值定量评价髓核蛋白多糖含量的研究

Quantitative evaluation of proteoglycan in lumbar disc with diffusion weighted ADC value:an experimental study

目的:探讨ADC值对髓核蛋白多糖含量的定量评价价值。材料与方法:腰椎间盘突出症患者拟行手术者,术前行弥散加权成像(DWI),并测量正中矢状面腰椎间盘的ADC值;术后测量髓核蛋白多糖含量。依据Minna tertti法将退变椎间盘进行分类,比较各类椎间盘髓核ADC值及蛋白多糖含量间的差异性,对各类腰椎间盘平均ADC值与退变椎间盘髓核的蛋白多糖含量进行相关性分析。结果:13例腰椎间盘突出症患者手术中摘除15个髓核标本,其中Ⅱ类椎间盘髓核7例,Ⅲ类椎间盘髓核8例;Ⅱ类椎间盘髓核ADC值与蛋白多糖相关系数r为0.826,P<0.05。Ⅲ类椎间盘髓核ADC与蛋白多糖相关系数r值为0.210,P>0.05。结论:ADC值可间接反映椎间盘髓核蛋白多糖含量变化,并可对早期椎间盘退变进行无创定量评价。

Objective： To study the value of diffusion-weighted imaging ADC values for quantitative evaluation of proteo- glycan in lumbar disc. Materials and Methods： ＇The ADC value of lumbar disc in patients with lumbar disc herniation was measured with diffusion-weighted imaging before operation. The content of proteoglycan in the surgical removal nucleus pulpo- sus was assessed. Degenerative disc were categorized with Minna tertti＇s method. The difference of proteoglycan and average ADC value for various degenerative lumbar discs were assessed. The correlation of the content of proteoglycan with ADC in disc degeneration was analyzed. Results： Fifteen surgical removal specimen of lumbar disc were obtained in 13 patients with lumbar disc herniation. There are 7 grade Ⅱ and 8 grade Ⅲ degenerative lumbar disc. The correlation coefficient （r） between ADC value and proteoglycan in grade Ⅱ lumbar intervertebral disc was 0.826, P〈0.05. The correlation coefficient r between ADC and proteoglycan in grade Ⅲ lumbar intervertebral disc was 0.210, P〉0.05. Conclusions： ADC values can be used to e- valuate the content of polysaccharides and collagen protein in lumbar disc indirectly.