血脂在下呼吸道感染患者中的临床意义

Clinical significance of plasma lipids in patients with lower respiratory tract infections

目的:探讨下呼吸道感染患者血脂水平与病情严重度以及预后的关系。方法:采用酶偶联比色法对我院70例社区获得性肺炎患者(非重症肺炎组)、32例重症肺炎患者(重症肺炎组,其中存活20例,死亡12例)和60例慢性阻塞性肺疾病(COPD)患者(COPD组)的甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、脂蛋白(a)[Lp(a)]浓度进行检测。结果:非重症肺炎组和COPD组患者入院时TG、HDL-C均较出院时显著降低,差异有统计学意义(P<0.05);和非重症肺炎组比,重症肺炎组HDL-C、LDL-C显著降低,差异有统计学意义(P<0.05);重症肺炎组死亡者与存活者比较,HDL-C水平降低,差异有统计学意义(P<0.05)。结论:HDL-C水平对下呼吸道感染患者的病情严重度评估以及预后判断有意义。

L Objective： To explore the relationship between plasma lipids and the severity and prognosticimplications of patients with lower respiratory tract infections. Methods： Using enzyme-colorimetric method, triglyceride （TG）, total cholesterol （TC）, high density lipoprotein cholesterol （HDL-C）, low density lipoprotein cholesterol （LDL-C）, lipoprotein （a） [LP（a）] were measured separately in 70 patients with community-acquired pneumonia, 32 patients with severe pneumonia and 60 patients with chronic obstructive pulmonary d^sease （COPD）. Results： Significantly lower concentrations of TG and HDL-C in patients with community-acquired pneumonia and COPD on admission were found as compared to hospital discharge; The HDL-C and LDL-C concentrations of the patients with severe pneumonia were significantly lower than that in the patients with community-acquired pneumonia; Patients with not surviving severe pneumonia were significantly lower HDL- C concentrations on admission than survivors. There were statistically significant differences between each group comparisons （P〈0.05）. Conclusion： Plasma HDL-C level can reflect the severity of disease and have prognostic implications in patients with lower respiratory tract infections.