首发精神分裂症患者的信息处理速度及其影响因素

Information processing speed and related factors in first-episode schizophrenia

目的探讨首发精神分裂症患者的信息处理速度及其相关影响因素。方法采用精神分裂症认知功能成套测验(MCCB)评估79例首发精神分裂症患者和54例正常对照者信息处理速度,并用阳性和阴性症状量表(PANSS)评估病例组临床症状。结果病例组在信息处理速度总分及连线、符号编码、言语流畅性三个分测验成绩明显差于对照组,差异有统计学意义(P<0.01)。性别、首发年龄、家族史、病程与首发精神分裂症患者信息处理速度相关。结论首发精神分裂症患者认知功能的信息处理速度有明显的损害,可能受首次发病年龄、家族史、性别、病程等因素影响。

Objective To explore the information processing speed and the related factors in first-episode schizophrenia. Methods Information processing speed of 79 cases of first-episode schizophrenia and 54 healthy con- trois was assessed with the matrics consensus cognitive battery （ MCCB ）. The clinical symptoms of patients were evalu- ated with the positive and negative syndrome scale （PANSS）. Results The patients＇ information processing speed, their scores in trail making test, symbol coding and verbal fluency test were significantly lower than those of the con- trols. Gender, age of first onset, family history and course of disease were closely related to the information processing speed in first-episode schizophrenia. Conclusion The information processing speed of cognitive function in first-epi- sode schizophrenia is significantly impaired. Age of first onset, family history, gender and course of disease are associ- ated with the processing speed in first-episode schizophrenia.