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慢性牙周炎患者IL-17mRNA的表达及意义 被引量：3

The expression of interleukin-17 in gingival tissues from patients with chronic periodontitis
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摘要 目的:观察IL-17mRNA基因在慢性牙周炎和健康牙龈组织中的表达水平变化,探讨IL-17在慢性牙周炎发生发展中的作用。方法:选择慢性牙周炎患者23例,正常对照组15例,记录牙周临床指标,采用Real-time PCR方法定量检测IL-17mRNA在牙龈组织中的表达。结果:慢性牙周炎组IL-17mRNA相对表达量(0.00147±0.00055)显著高于正常牙龈组(0.00047±0.00019)(P<0.01),并且慢性牙周炎组IL-17mRNA表达水平与牙龈指数(r=0.58,P<0.01)、牙周袋探诊深度(r=0.57,P<0.01)、附着丧失水平(r=0.49,P<0.05)呈正相关。结论:Th17相关细胞因子IL-17可能在慢性牙周炎发病机制中发挥致炎作用。 Objective：To evaluate the expression of II,-17mRNA in gingival tissues from patients with chronic peri- odontal disease in comparison with normal control subjects. Method： Gingival samples from patients with chronic periodonti- tis and normal subjects were collected and used for the subsequent assays. The messenger RNA expression tbr the cylokines IL-17 was evaluated by real-time quantitative polymerase ehain reaction.Before sampling, the clinical periodontal indices were recorded. Result： Our data demonstrated the levels of IL-17 messenger RNA in diseased tissues were increased （P 〈 0.01） compared with normal tissues. The level of IL-17 expression in periodontitis was positively correlated with gingival in- dex probing depth and attachment level. Conclusion：ThlT-related cytokines IL-17 might play an important role in the pathogenesis of chronic periodontitis.
作者 张旭 汪饶饶 徐远志 唐小山 尚光伟
机构地区 同济大学附属上海第十人民医院口腔科
出处 《临床口腔医学杂志》 2013年第9期524-526,共3页 Journal of Clinical Stomatology
关键词 慢性牙周炎 TH17 白细胞介素-17 实时定量PCR chronic periodontitis： T help cell 17 ： interleukin- 17： real-time polymerase chain reaction
分类号 R781.4 [医药卫生—口腔医学]
  • 相关文献

参考文献19

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二级参考文献24

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共引文献20

同被引文献38

  • 1赵建中,姚加平.婴幼儿感染者血清TNF、IL-6、IL-8联检的临床意义[J].放射免疫学杂志,2005,18(3):185-186. 被引量：35
  • 2Oppmann B,Lesley R,Blom B. Novel p19 protein engages IL-12p40 to form a eytokine,IL-23,with biological activities similar as well as distinct from IL-12[J].Immnity,2000,(05):715-725.
  • 3Langrish CL,Chen Y,Blumenschein WM. IL23 drives apathogenic T cell population that induces autoimmune inflammation[J].Journal of Experimental Medicine,2005,(1 5):233-240.
  • 4Iwakura Y,Ishigame H. The IL-23/IL-17 axis in inflammation[J].Journal of Clinical Investigation,2006,(05):1218-1222.
  • 5Ohyama H,Kato-Kogoe N,Kuhara A. The involvement of IL-23 and the Th17 pathway in periodontitis[J].Journal of Dental Research,2009,(07):633-638.doi:10.1177/0022034509339889.
  • 6Leo H. The gingival index the plaque index and the retention index system[J].Journal of Periodontology,1967,(06):610-616.
  • 7Ohlrich EJ,Cullinan MP,Seymour GJ. The immunopathogenesis of periodontal disease[J].Australian Dental Jonrnal,2009,((Suppl)1):S2-10.
  • 8Arun KV,Talwar A,Kumar TS. T-helper cells in the etiopathogenesis of periodontal disease:A mini review[J].Indian Soc Periodontol,2011,(01):4-10.
  • 9Harrington LE,Hatton RD,Mangan PR. Interleukin 17-producing CD4+effector T ceils develop via alineage distinct from the T helper type l and 2 lineages[J].Nature Immunology,2005,(11):1123-1132.doi:10.1038/ni1254.
  • 10Zhu L,Wu Y,Wei H. Up-regulation of IL-23 p19 expression in human periodontal ligament fibroblasts by IL-1β via concurrent activation of the NF-κB and MAPKs/AP-1 pathways[J].CYTOKINE,2012,(01):171-178.

引证文献3

二级引证文献5

临床口腔医学杂志
2013年 第9期

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