RKIP在舌癌组织及转移淋巴结中的表达及意义

Expression and significance of RKIP in human tongue squamous cell carcinoma and their metastatic lymph nodes

目的:探讨RKIP在舌癌组织及转移淋巴结中的表达及意义。方法:应用免疫组化法检测RKIP在60例舌癌组和癌旁组织表达情况,比较舌癌分化良好组和分化不良组RKIP表达,将舌癌淋巴结转移组和淋巴结无转移组RKIP表达进行比较。结果:舌癌组和癌旁组织相比,RKIP表达水平明显下降,两者之间有统计学差异(P<0.05)。舌癌分化良好组RKIP表达高,分化不良组表达低,RKlP与舌癌病理分级之间,有相关关系(P<0.05)。转移淋巴结RKIP表达低。结论:RKIP具有抑制舌癌转移的作用,其表达的上调能促进舌癌的分化,抑制舌癌的转移。

Objective：To investigate the expression and significance of RKIP （Raf kinase inhibitor protein）in human tongue squamous cell carcinoma and their metastatic lymph nodes, and to evaluate RKIP＇S relationship with tongue squa- mous cell carcinoma＇S pathological classification. Method：The expressions of RKIP in 60 cases tongue squamous cell carci- noma tissues and 60 cases adjacent to cancer tissues were tested by immunofluorescence histochemistry staining.The expres- sions of RKIP in 30 cases their metastatic lymph nodes and 30 cases Non metastatic lymph nodes were tested by im- munofluorescence histochemistry staining.The relationship between tongue squamous cell carcinoma＇s pathological classifi- cation was analyzed. Result：The expression of RKIP in tongue squamous cell carcinoma tissues was obviously lower than that of adjacent to cancer tissues; its expression in dys-good differentiation group was significantly lower than that of good differentiation group;while RKIP expression was lower in metastatic lymph nodes than in Non metastatic lymph nodes. Conclusion：RKIP is a new metastasis suppressor gene, and its increased expression can decrease tongue squamous cell car- cinoma＇s invasive capability and promote tongue squamous cell carcinoma＇s differentiation.