EB病毒感染与肺癌患者临床特征的相关性

Correlation of Epstein-Barr virus infection and clinical features of patients with lung cancer

目的探讨EB病毒(EBV)相关肺癌的临床特征。方法采用原位杂交法检测108例手术切除肺癌标本和22例癌旁正常组织的EBV编码小RNA1(EBER-1)的表达。结果肺癌标本中EBER-1阳性率为33.3%,高于癌旁正常肺组织的4.5%(P<0.01)。右肺癌EBER-1阳性率为40.3%,高于左肺癌的19.4%(P<0.05)。77例鳞癌和腺癌中,高、中、低分化癌的EBER-1阳性率分别为8.3%、47.2%、27.6%,组间比较差异有统计学意义(P<0.05)。结论 EBV感染可能与肺癌的发病部位、分化程度相关。

Objective To analyze the clinical features of patients with Epstein-Barr virus （EBV）-related lung cancer. Methods EBV-encoded small RNA-1 （EBER-1） was detected by in situ hybridization in surgically resected lung cancer samples（ 108 cases） and tumor-adjacent normal lung tissues （22 cases）. Results The positive rate of EBER-1 was higher in lung cancer samples（33.3%） than that in tumor-adjacent normal tissues （4. 5%）（P〈0. 01）, which was higher in the lung cancers on the right side （40. 3%） than that in those on the left （19.4%） （P〈0. 05）. Of 77 cases with squamous carcinoma and adenocarcinoma, the positive rates of EBER-1 were 8. 3%, 47.2% 27.6% in well, moderately and poorly differentiated samples, respectively （P〈0. 05）. Conclusion EBV infection may be related to lesion location and degree of differentiation in patients with lung cancer.