感染性心内膜炎住院病死率的预测因素

Predictors of in-hospital mortality in patients with infective endocarditis

目的研究感染性心内膜炎(IE)住院病死率的预测因素。方法回顾性分析133例IE患者资料。结果 133例IE患者中23例死亡,住院病死率17.3%。与住院病死率相关的因素包括ALT>40U/L、Cr>106μmol/L、WBC>15×109/L、C反应蛋白(CRP)>40mg/L、NYHA心功能分级Ⅲ-Ⅳ级、感染严重度、赘生物直径≥1cm和栓塞事件(P<0.05);将其纳入二元Logistic回归分析后发现,NYHA心功能分级Ⅲ-Ⅳ级、恶性感染、赘生物直径≥1cm、栓塞事件是住院病死率的独立预测因素(P<0.05)。结论赘生物大小、NYHA心功能分级、感染、栓塞事件是IE患者住院病死率的独立预测因素。

Objective To analyze the predictors of in-hospital mortality in the patients with infective endocarditis（IE）. Methods Clinical data of 133 IE patients were analyzed retrospectively. Results Of 133 IE patients,23 cases were in-hospital death with an in-hospital mortality of 17. 3o/00. The factors related to in-hospital mortality included ALTO40 U/L, Cr〉106/zmol/L, WBC〉 15 ）〈 109/L,CRP^40 mg/L, NYHA class I]I-1V grade, serious infection, vegetation diameter~ 1 cm, and embolic events（P^0. 05）. NYHA class Ⅲ-IV grade, serious infection,vegetation diameter〉l cm, and embolic events were the independent predictors of in-hospital mortality （P〈0. 05 ）. Conclusion Vegetation size,NYHA class,infection, and embolie events are the important predictors of in hospital mortality in IE patients.