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光线性角化病76例临床及组织病理分析 被引量:4

Clinical Pathological Analysis of 76 Cases of Actinic Keratosis
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摘要 目的探讨光线性角化病的临床及组织病理学特点,减少其误诊率和漏诊率。方法对76例经过活检确诊为光线性角化病患者的临床资料进行回顾性分析。结果 76例患者中,平均年龄(75.22±11.37)岁;平均病程(3.53±6.25)年;男∶女发病比例为1∶1.24;皮损发生于面部的患者最多(73例,96.05%);临床表现:淡红色斑片10例(13.16%),淡褐色斑片3例(3.95%),角化性丘疹26例(34.21%),角化性斑块32例(42.11%),溃疡2例(2.63%),皮角3例(3.95%);组织病理分型:肥厚型25例(32.89%),萎缩型17例(22.37%),棘层松解型8例(10.53%),色素型4例(5.26%),苔藓样型和鲍恩样型各11例(14.47%)。其中4例(5.26%)发展为侵袭性鳞癌。76例的真皮浅层均可见明显日光弹性纤维变性,并可见不同程度的以淋巴细胞为主的浸润。结论光线性角化病好发于老年人的曝光部位,以面部多见,临床表现多样,病理亚型以肥厚型和萎缩型多见,可发展为侵袭性鳞癌,需要临床医生重视。 Objective To study the clinical and histopathological features of actinic keratosis in order to reduce the misdiagnosis rate and missed diagnosis rate. Methods The clinical data of 76 cases of actinic keratosis diagnosed by biopsy were analyzed retrospectively. Results The mean age was (75.22 ± 11.37 ) years. The mean course was(3.53 ±6.25 )years. The ratio of male/female was 1 : 1.24. The most frequently affected area was face (73 cases, 96. 05% ). The lesions were reddish macules (13. 16% ), brownish macules ( 3.95% ), keratotic papules ( 34.21% ), keratotic plaques ( 42.11% ) , cutaneous horns ( 3.95% ) and ulcers(2.63% ). Histopathological changes included hypertrophy(32.89% ), atrophy(22.37% ), acantholysis( 10.53% ) , pigmentation (5.26%) , lichenoid change ( 14.47% ) and bowenoid change ( 14.47% ). Four cases(5.26% ) developed to invasive SCC. All the cases showed solar elastosis and lymphocyte infiltration in dermis. Conclusion AK develops mostly on sun-exposed areas, especially face, in the old people with various presentations. The main histologic features are hypertrophy type and atrophy. AK can develop to invasive SCC and should be paid more attention.
出处 《中国皮肤性病学杂志》 CAS 北大核心 2013年第10期1023-1025,共3页 The Chinese Journal of Dermatovenereology
关键词 角化病 光线性 Keratosis, actinic
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参考文献10

  • 1Ackerman AB, Mones JM. Solar(actinic) keratosis is squamous cell car- cinoma[ J]. Br J Dermatol,2006,155 ( 1 ) :9 - 22.
  • 2Roewert-Huber J, Stockfleth E, Kerl H. Pathology and pathobiology of ac- tinic (solar) keralosis-an update [ J ]. Br J Dermatol, 2007,157 ( 2 ) : 18 -20.
  • 3Weedon D. Skin Pathology[ M ]. 2nd ed. London : Churchill Livingstone, 2002:761 - 762.
  • 4龙庭凤,刘流,何黎,沈丽达,柴燕杰,袁瑞红,杨亚萍.日光性角化病90例临床及病理特征分析[J].临床皮肤科杂志,2010,39(5):286-289. 被引量:9
  • 5Rowert-Huber J, Patel M J, Forschner T, et al. Actinic keratosis is an early in situ squamous cell carcinoma : a proposal for reclassification [ J ]. Br J Dermatol,2007,156 ( 3 ) : 8 - 12.
  • 6Rossi R, Mori M, Lotti T. Actinic keratosis [ J 1- Int J Dermatol,2007, 469 (7) : 895 - 904.
  • 7廖文俊,樊平申,王雷,李承新,高天文.光线性角化病132例临床及组织病理分析[J].临床皮肤科杂志,2009,38(7):423-426. 被引量:6
  • 8Bagazgoitia L,Cuevas J,Juarranz A. Expression of p53 and p16 in actin- ic keratosis, bowenoid actinic keratosis and Bowen's disease [ J ]. JEADV ,2010 ,24 ( 2 ) :228 - 230.
  • 9Ramzi ST, Maruno M, Khaskhely NM,et al. An assessment of the ma- lignant potential of actinic keratoses and Bowen's disease : p53 andPCNA expression pattern correlate with the nmnber of desmosomes [ J ]. J Der- matol,2002,29 (5) :562 - 572.
  • 10Memon AA, Tomenson JA, Bothwell J, et al. Pvalence of solar dam- age and actinic keratosis in a Merseyside population [ J ]. Br J Derma- tol,2000,142 (6) : 1154 - 1 159.

二级参考文献19

  • 1王爱民,成建新,刘超美,王秀清.日光性角化病合并鳞状细胞癌和皮角1例[J].临床皮肤科杂志,1996,25(1):44-45. 被引量:2
  • 2Ackerman AB,Mones JM.Solar (actinic) keratosis is squamous cell carcinoma[J].Br J Dermatol,2006,155(1):9-22.
  • 3Rossi R,Mori M,Lotti T.Actinic keratosis[J].Int J Dermatol,2007,46(9):895-904.
  • 4López-Tizón E,Mencía-Gutiérrez E,Garrido-Ruíz M,et al.Clinicopathological study of 21 cases of eyelid actinic keratosis[J].Int Ophthalmol,2008.[Epub ahead of print]
  • 5Rowert-Huber J,Patel M J,Forschner T,et al.Actinic keratosis is an early in situ squamous cell carcinoma:a proposal for reclassification[J].Br J Dermatol,2007,156 Suppl 3:8-12.
  • 6Anwar J,Wrone DA,Kimyai-Asadi A,et al.The development of actinic keratosis into invasive squamous cell carcinoma:evidence and evolving classification schemes[J].Clin Dermatol,2004,22(3):189-196.
  • 7Reagan-Shaw S,Mukhtar H,Ahmad N.Resveratrol imparts photo-protection of normal cells and enhances the efficacy of radiation therapy in cancer cells[J].Photochem Photobiol,2008,84(2):415-421.
  • 8Ackerman AB,Mones JM.Solar (actinic) keratosis is squamous cell carcinoma[J].Br J Dermatol,2006,155(1):9-22.
  • 9James C,Crawford RI,Martinka M,et al.Actinic keratosis[A].In:WHO Pathology Genetics,Skin Tumors[M].Lyon:1ARC Press,2006:30-33.
  • 10da Silva TA,Coelho G,Lorenzetti Bocca A,et al.Expression of apoptotic,cell proliferation regulatory,and structural proteins in actinic keratosis and their association with dermal elastosis[J].J Cu-tan Pathol,2007,34(4):315-323.

共引文献13

同被引文献18

  • 1赵辨.中国临床皮肤病学[M].南京:江苏科学技术出版社,2009,12:744.
  • 2Anwar J,Wrone DA, Kimyai-Asadi A, et al. The development of actinic keratosis into invasive squamous cell carcinoma: evidence and evolving classification schemes [ J ]. Clin Dermatol, 2004,22 ( 3 ) : 189 - 196.
  • 3Zalaudek I,Piana S,Moscarella E,et al. Morphologic grading and treat- ment of facial actinic keratosis [ J ]. Clinics in Dermatology, 2014,32 (1) :80 -87.
  • 4Memon AA,Tomenson JA,Bothwell J, et al. Prevalence of solar damage and actinic keratosis in a Merseyside population [ J ]. Br J Dermatol, 2000,142(6) :1154 - 1159.
  • 5Roewert-Huber J, Stockfleth E, Kerl H. Pathology and pathobiology of ac- tinic(solar) kera/osis-an update [ J ]. Br J Dermatol, 2007,157 ( Suppl 2) :18 -20.
  • 6Moy RL. Clinical presentation of actinic keratoses and squamous cell car- cinoma[J]. J Am Acad Dermatol,2000,42(1Pt2) :8 - 10.
  • 7Ko CJ. Actinic keratosis : facts and controversies [ J ]. Clinics in Dermatol- ogy,2010,28 ( 3 ) : 249 - 253.
  • 8Ferr6ndiz C, Fonseca-Capdevila E, Garcta-Diez A, et al. Spanish adapta- tion of the European guidelines for the evaluation and treatment of actin- ic keratosis [ J ]. Actas Demosifiliogr,2014,105 ( 4 ) : 378 - 393.
  • 9廖文俊,樊平申,王雷,李承新,高天文.光线性角化病132例临床及组织病理分析[J].临床皮肤科杂志,2009,38(7):423-426. 被引量:6
  • 10龙庭凤,刘流,沈丽达,李坤杰,杨亚萍,陈文颖,涂颖,何黎.90例确诊日光性角化病临床特征分析[J].皮肤病与性病,2010,32(1):12-15. 被引量:7

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