酮咯酸氨丁三醇超前镇痛对老年创伤患者术后认知功能的影响被引量：3

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摘要非甾体类抗炎药物的脑保护作用越来越受到人们关注[1].目前的研究表明,术后使用非甾体类抗炎镇痛药氟比洛芬酯可降低老年患者术后认知功能障导（postoperative cognitive dysfunction,POCD）的发生率[2].超前镇痛即在疼痛刺激之前使用镇痛药物,防止手术引起的损伤刺激向中枢传递及神经中枢过敏化,从而达到减轻术后疼痛的目的,可降低术后镇痛药的用量.但酮咯酸氨丁三醇（ketorolac tromethamine,KT）超前镇痛对老年创伤患者术后认知功能的影响目前未见报道.笔者探讨KT超前镇痛对老年创伤患者认知功能的影响及可能机制.

作者贺纯静严晓寒章放香冯亚平

机构地区贵州省人民医院麻醉科

出处《中华创伤杂志》 CAS CSCD 北大核心 2013年第9期868-870,共3页 Chinese Journal of Trauma

关键词酮咯酸氨丁三醇认知功能超前镇痛老年患者创伤患者非甾体类抗炎镇痛药非甾体类抗炎药物神经中枢

分类号 R614 [医药卫生—麻醉学]

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参考文献10

1Takada M, Fukusaki M, Terao Y, et al. Preadministration of flurbiprofen suppres-ses prostaglandin production and postoper- ative pain in orthopedic patients undergo- ing tourniquet inflation. J Clin Anesth, 2007, 19(2) :97 - 100.
2贺纯静,聂浩雄,郭春芮,章放香.氟比洛芬酯术后镇痛对老年髋关节置换术患者术后认知功能的影响[J].临床麻醉学杂志,2013,29(1):13-15. 被引量：41
3Svensson CI, Yaksh TL. The spinal phos- pholipase - eyclooxygenase - prostanoid cas- cade in nociceptive processing. Annu Rev Pharmaeol Toxicol, 2002, 42:553 -583.
4Kehlet H, Dahl JB. The value of "multi- modal" of " balanced analgesia" in post- operalive pain treatment. Anesth Analg, 1993, 77(5) :1148 - 1156.
5徐府奇,王琛,谢红.氟比洛芬酯对颅脑手术患者超敏C反应蛋白的影响[J].临床麻醉学杂志,2009,25(4):290-291. 被引量：4
6Selnes OA, Grega MA, Borowicz LM Jr, et al. Cognitive outcomes three years after coronary artery bypass surgery: a compari- son of on - pump coronary artery bypass graft surgery and nonsurgical controls. Ann Thorac Surg, 2005, 79(d):1201 -1209.
7Nakayama M, Ichinose H, Yamamoto S, et al. Perioperative intravenous flurbipro- fen reduces postoperative pain after ab- dominal hysterectomy. Can J Anaesth, 2001, 48(3) :234 -237.
8Yamashita K, Fukusaki M, Ando Y, et al. Preoperative administration of intrave- nous flurbiprofen axetil reduces postopera- tive pain for spinal fusion surgery. J.Anesth, 2006, 20(2):92-95.
9Edaravone Acute InSarction Study Group. Effect of a novel free radical scavenger, edaravone(MIC- 186), on acute brain in- farction. Randomized, placebo - controlled, double- blind study at multicente. Cere- brovasc Dis, 2003, 15(3):222-229.
10Silbert BS, Scott DA, Evered LA, et al. A comparison of the effect of high - and low- dose fentanyl on the incidence of postoperative cognitive dysfunction after coronary artery bypass surgery in the eld- erly. Anesthesiology, 2006, 104 (6) : 1137 - 1145.

二级参考文献15

1樊启光,张媛媛.血清超敏C反应蛋白测定在急性脑血管病中的临床意义[J].中国实用医药,2007,2(19):21-22. 被引量：13
2段砺瑕,李晓玲.氟比洛芬酯注射液的药理作用及临床应用[J].中国新药杂志,2004,13(9):851-852. 被引量：601
3Gong C, Hoff JT, Keep RF. Acute inflammatory reaction following experimental intraceerbral hemorrhage in rats. Brain Res,2000,871 :57-65.
4Rifai N, Ridker PM. High sensitity C-reactive protein: a novel and promising marker of coronary heart disease. Clin Chem, 2001,47:403- 411.
5Yoshitani K, Kawaguchi M, Tatsumi K, et al. Intravenous administration of flurbiprofen does not affect cerebral blood flow velocity and cerebral oxygenation under isoflurane and propofol anesthesia. Anesth Analg, 2004,98 :471-476.
6Hirota K, Fukushi S, Baba S, et al. Flurbiproten does not change the bispectral index and 95% spectral edge frequency during total intravenous anesthesia with propofol and fentany. Eur J Anaesthesiol, 2002,19 : 483-486.
7许绍强.超敏C反应蛋白在颅脑疾病中的应用价值[J].现代医院,2007,7(11):20-22. 被引量：16
8Takada M,Fukusaki M,Terao Y. Pread ministration of flurbiprofen suppresses prostaglandin production and postoperative pain in orthopedic patients undergoing tourniquet inflation[J].Journal of Clinical Anesthesia,2007,(02):97-100.
9Parepally JM,Mandula H,Smith QR. Brain uptake of nonsteroidal anti-inflammatory drugs:ibuprofen,flurbiprofen,and indomethacin[J].Pharmaceutical Research,2006,(05):873-881.
10Kehlet H,Dahl JB. The value of multimodal or balanced analgesia in postoperative pain treatment[J].Anesthesia and Analgesia,1993,(05):1048-1056.