期刊文献+

JAK-STAT信号通路在类风湿关节炎中的研究进展 被引量:8

原文传递
导出
摘要 JAK-STAT信号通路是介导细胞因子信号转导的重要路径之一,其通过多种途径参与炎性反应并在信号转导途径中扮演重要的调控角色。近年来,JAK-STAT信号通路与多种疾病的关联性引起了人们兴趣。本文综述JAK-STAT在RA中的研究进展。
出处 《现代免疫学》 CAS CSCD 北大核心 2013年第5期425-428,共4页 Current Immunology
基金 国家自然科学基金面上项目(31270963) 上海市科委重点项目(10JC1408500) 上海市科委重点学科(外科学)开放课题(S30204-K01) 上海市科委自然基金项目(10ZR1426100 11ZR1427000)
  • 相关文献

参考文献24

  • 1赵蓉,许荣,周晓薇,苗平,钱柳,余奇文,张继英,陈雪华,张冬青.抗胶原Ⅱ功能域抗体诱导的RA样小鼠模型的建立及其免疫病理学指标分析[J].现代免疫学,2013,33(1):6-11. 被引量:5
  • 2黄秋愉,许荣,钱柳,胡朝英,程伟志,苗平,余奇文,张继英,陈雪华,李卓伶,张冬青.类风湿关节炎患者关节损伤相关因子和EBV抗体检测的意义[J].现代免疫学,2010,30(6):482-487. 被引量:4
  • 3Kiu H,Nicholson SE.Biology and significance of the JAK-STAT signalling pathways [J].Growth Factors,2012,30:88-106.
  • 4Aaronson DS,Horvath CM.A road map for those who don't know JAK-STAT [J].Science,2002,296:1653-1655.
  • 5Choy E.Understanding the dynamics; pathways involved in the pathogenesis of rheumatoid arthritis [J].Rheumatology (Oxford),2012,51:v3-ll.
  • 6Walker JG,Smith MD.The Jak-STAT pathway in rheumatoid arthritis [J].J Rheumatol,2005,32:1650-1653.
  • 7高薇,杨娉婷,赵丽娟.JAK/STAT信号转导通路与类风湿关节炎[J].中华风湿病学杂志,2006,10(9):563-566. 被引量:12
  • 8Kasperkovitz PV,Verbeet NL,Smeets TJ,et at.Activation of the STATI pathway in rheumatoid arthritis [J].Ann Rheum Dis,2004,63 ; 233-239.
  • 9Gordon RA,Grigoriev G,Lee A,et al.The interferon signature and STATl expression in rheumatoid arthritis synovial fluid macrophages are induced by tumor necrosis factor a and counter-regulated by the synovial fluid microenvironment [J].Arthritis Rheum,2012,64:3119-3128.
  • 10Krause A,Sealetta N,Ji J,et al,Rheumatoid arthritis synoviocyte survival is dependent on Stat3 [J],J Immunol,2002,169:6610-6616.

二级参考文献38

  • 1Agarwal V, Singh R, Chauhan S. Remission of rheumatoid arthritis after acute disseminated varicella-zoster infection [J]. Clin Rheumatol, 2007,26:779-780.
  • 2Toussirot E, Roudier J. Epstein Barr virus in autoimmune diseases[J]. Best Pract Res Clin Rheumatol, 2008,22:883- 896.
  • 3Olson JK, Croxford JL, Miller SD. Virus-induced autoimmunity: potential role of viruses in initiation, perpetuation, and progression of T-cell-mediated autoimmune disease [J]. Viral Immunol, 2001,14:227-250.
  • 4Kurosaka D, Hirai K, Nishioka M, et al. Clinical significance of serum levels of vascular endothelial growth factor, angiopoietin-1, and angiopoietin-2 in patients with rheumatoid arthritis[J]. J Rheumatol, 2010,37:1121-1128.
  • 5Rooney T, Roux-Lombard P, Veale DJ, etal. Synovial tissue and serum biomarkers of disease activity, therapeutic response and radiographic progression: analysis of a proof-ofconcept randomised clinical trial of cytokine blockade [J]. Ann Rheum Dis, 2010,69:706-714.
  • 6Toussirot E, Wendling D, Tiberghien P, etal. Decreased T cell precursor frequencies to Epstein-Barr virus glycoprotein gp110 in peripheral blood correlate with disease activity and severity in patients with rheumatoid arthritis [J]. Ann Rheum Dis, 2000,59:533-538.
  • 7SaM JG, Krimmel M, Steidle M, et al. Synovial Epstein- Barr virus infection increases the risk of rheumatoid arthritis in individuals with the shared HLA-DR4 epitope[J]. Arthritis Rheum, 1999,42:1485-1496.
  • 8Agarwal V, Singh R, Chauhan S. Remission of rheumatoid arthritis after acute disseminated varicella-zoster infection [J]. Clin Rheumatoi, 2007,26:779-780.
  • 9Levy DE,Damell JE Jr.Stats:transcriptional control and biological impact.Nat Rev Mol Cell Biol,2002,3:651-662.
  • 10..JAK-STAT信号转导通路..黄文林,朱孝峰,主编..信号转导..北京:人民卫生出版社,,2005..182-199..

共引文献18

同被引文献98

引证文献8

二级引证文献82

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部