大肠杆菌不耐热肠毒素B亚单位作为黏膜免疫佐剂的研究
摘要
大肠杆菌不耐热肠毒素B亚单位(LTB)是大肠杆菌不耐热肠毒素(LT)的组成部分之一,具有免疫原性,但无毒性,是一种较为理想的黏膜免疫佐剂。本文就大肠杆菌不耐热肠毒素B亚单位的分子结构、介导的免疫反应及其黏膜免疫佐剂效应作一综述。
出处
《现代免疫学》
CAS
CSCD
北大核心
2013年第5期429-432,共4页
Current Immunology
基金
国家自然科学基金(81172890)
参考文献23
-
1郑继平,刘向昕,王令春,李淑琴,方门忠,张兆山.产肠毒素大肠杆菌混合载体疫苗的免疫原性评价[J].现代免疫学,2004,24(6):482-485. 被引量：2
-
2Salimian J,Salmanian AH,Khalesi R,et al.Antibody a-gainst recombinant heat labile enterotoxin B subunit (rLTB) could block LT binding to ganglioside Ml receptor[J].Iran J Microbiol,2010,2:120-127.
-
3Christelle B,Fatou T,Cyrille DM,et al.Cholera-like enter-otoxins and regulatory T cells [J].Toxins,2010,2:1774-1795.
-
4Mario JB,Scerbo MJ,Nahuel P,et al.The hybrid between the ABC domains of synapsin and the B subunit of Escherichia coli heat-labile toxin ameliorates experimental autoimmune encephalomyelitis[J],Cell Immunol,2012,280:50-60.
-
5Andre AG,Samuel RF,Carolina XS,et al.Protection a-gainst lethal leptospirosis after vaccination with LipL32 coupled or coadministered with the B subunit of Escherichia coli heat-labile enterotoxm[J].Clin Vaccine Immunol,2012,19:740-745.
-
6Shuang L,Kavita BH,Hesham FN,et al.In vivo and in vitro adjuvant activities of the B subunit of type IIb heat-labile enterotoxin (LT-IIb-B5) from Escherichia coli[J].Vaccine,2009,27:4302-4308.
-
7Kim JM,Park SM,Kim JA,et al.Functional pentameric formation via coexpression of the Escherichia coli heat-labile enterotoxin B subunit and its fusion protein subunit with a neutralizing epitope of apxIIA exotoxin improves the mucosal immunogenicity and protection against challenge by Actinoba-cillus pLeuropneumoniae [J].Clin Vaccine Immunol,2011,18:2168-2177.
-
8Benjamin M,Meta Jk.Heat-labile enterotoxin:Beyond GMl binding[J].Toxins,2010,2:1445-1470.
-
9Turcanu V,Hirst TR,Williams NA.Modulation of human monocytes by Escherichia coli heat-labile entertoxin B-sub-unit ; altered cytokine production and its functional conse-quences[J].Immunology,2002,106:316-325.
-
10Donaldson DS,Apostolaki M,Bone HK,et al.The Esche-richia coli heat-labile enterotoxin B subunit protects from allergic airway disease development by inducing CD4 + regulatory T cells[J].Mucosal Immunol,2012,93:1-12.
二级参考文献6
-
1Black RE. Epidemiology of diarrhoeal disease:implications for control by vaccines[J]. Vaccine,1993,11:100.
-
2Levine MM,Ristaino P,Marley G,et al. Coli surface antigens I and 3 of colonization factor antigen II-positive enterotoxigenic Escherichia coli:morphology,purification,and immune responses in humans[J]. Infect Immun,1984,44:409.
-
3Ahren C,Wenneras C,Holmgren J,et al. Intestinal antibody response after oral immunization with a prototype cholera B subunit-colonization factor antigen enterotoxigenic Escherichia coli vaccine[J]. Vaccine,1993,11:929.
-
4Bary HM,Alboum Z,Losonsky G,et al. Immune responses elicited against multiple enterotoxigenic Escherichia coli fimbriae and mutant LT expressed in attenuated Shigella vaccine strains[J]. Vaccine,2003,21:333.
-
5Bennish ML,Wojtyniak BJ. Mortality due to shigellosis:community and hospital data[J]. Rev Infect Dis,1991,13(Suppl 4):S245.
-
6Kotloff KL,Winickoff JP,Ivanoff B,et al. Global burden of Shigella infections:implications for vaccine development and implementation[J]. Bull WHO,1999,77:651.
-
1马春梅,陈建忠.Th17细胞在霍乱毒素黏膜免疫佐剂效应中的作用[J].细胞与分子免疫学杂志,2012,28(11):1212-1213.
-
2严小芳,张佩,董硕.霍乱毒素无毒B亚单位(CTB)黏膜免疫佐剂的研究进展[J].生命科学,2009,21(1):53-55. 被引量：4
-
3鲁东水,毛旭虎,吴超,邹全明.大肠杆菌不耐热肠毒素B亚单位融合表达载体的构建及应用[J].第三军医大学学报,2003,25(14):1275-1277. 被引量：2
-
4冯强,杨珺,张卫军,郭桐生,刘开云,邹全明.大肠杆菌不耐热肠毒素B亚单位的分泌表达与性质鉴定[J].免疫学杂志,2004,20(5):364-368. 被引量：6
-
5田文标,邹全明,张卫军.大肠杆菌不耐热肠毒素B亚单位基因工程菌发酵工艺的研究[J].第三军医大学学报,2005,27(2):115-118. 被引量：4
-
6郝亚宁,马永平.关于黏膜免疫佐剂的研究现状[J].中国微生态学杂志,2009,21(7):661-663. 被引量：3
-
7崔文禹,李媛媛,单璞,凌媛,李计来,徐静.大肠杆菌不耐热肠毒素B亚单位的原核表达、纯化及其黏膜免疫佐剂作用[J].中国生物制品学杂志,2011,24(12):1417-1420. 被引量：1
-
8张玲华,邝哲师,田兴山.黏膜免疫佐剂研究进展[J].生物技术通讯,2006,17(6):957-960.
-
9刘林,周慧聪,王秋娟,陈思静,马永平.大肠不耐热肠毒素B亚单位佐剂活性相关蛋白的筛选[J].中国药理学通报,2016,32(12):1761-1766. 被引量：2
-
10黄思扬,马超,雷清,蒋琳,沈心亮,王锐.大肠杆菌不耐热肠毒素B亚单位的克隆、表达及初步纯化[J].生物技术,2005,15(6):17-20. 被引量：3
