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MicroRNA及其与肿瘤关系的研究 被引量：2

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摘要 MicroRNA（miRNA）是近年来发现的一类非蛋白编码的小分子RNA，广泛存在于动植物细胞中，长度通常为18～22个核苷酸残基，在基因的转录后调控中起到重要的作用，参与细胞生长，分化和凋亡等多种生理病理过程。研究发现miRNA与肿瘤的发生和转移有密切的关系，某些miRNA可参与肿瘤干细胞的增殖、分化和细胞凋亡等调控过程，起着癌基因或抑癌基因的作用，miRNA正成为肿瘤的诊断和治疗的新靶点。本文主要就miRNA的生物合成以及miRNA与肿瘤的关系进行综述。
作者 王红 刘兆远 王宏林
机构地区 上海交通大学医学院
出处 《现代免疫学》 CAS CSCD 北大核心 2013年第5期437-439,436,共4页 Current Immunology
基金 国家自然科学基金(NSFC-91029730) 上海市教委基金(JS0207)
关键词 MICRORNA 肿瘤
分类号 R392 [医药卫生—免疫学]
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参考文献18

  • 1Lee RC,Feinbaum RL,Ambros V.The C.elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 [J].Cell,1993,75:843-854.
  • 2Yang JS,Phillips MD,Betel D,etal.Widespread regulatory activity of vertebrate microRNA,species[J].RNA,2011,17:312-326.
  • 3StahlhutEspinosa CE,Slack FJ.The role of microRNAs in cancer[J].Yale J Biol Med,2006,79:131-140.
  • 4Hafner M,Landthaler M,Burger L,et al.Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP[J].Cell,2010,141:129-141.
  • 5Calin GA,Croce CM.MicroRNA signatures in human cancers [J].Nat Rev Cancer,2006,6:857-866.
  • 6Esquela-Kerscher A,Slack FJ.Oncomirs-microRNAs with a role in cancer[J].Nat Rev Cancer,2006,6:259-269.
  • 7Schetter AJ,Leung SY.Sohn JJ,et al.MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma[J].JAMA,2008,299:425-436.
  • 8Yang N,Kaur S,Volinia S,et al.MicroRNA microarray i-dentifies Let-7i as a novel biomarker and therapeutic target in human epithelial ovarian cancer[J].Cancer Res,2008,68:10307-10314.
  • 9Petrocca F,Visone R,Onelli MR,et al.E2Fl-regulated mi-croRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer[J].Cancer Cell,2008,13:272-286.
  • 10Garzon R,Marcucci G,Croce CM.Targeting microRNAs in cancer:rationale,strategies and challenges[J].Nat Rev Drug Discov,2010,9:775-789.

同被引文献26

  • 1Barrel DP. MicroRNAs: genomics, biogenesis, mechanism, and function[J]. Cell, 2004, 116(2):281- 97.
  • 2Ambros V. microRNAs~ tiny regulators with great potentia [J]. Cell, 2001, 107:823-826.
  • 3Lagos-Quintana M1, Rauhut R, Lendeckel W, et al, Identifi- cation of novel genes coding for small expressed RNAs [J]. Science, 2001, 294:853-858.
  • 4Cai Xl, Hagedorn CH, Cullen BR. Human microRNAs are processed from capped, polyadenylated transcripts that can also function asmRNAs[J]. RNA, 2004, 10 :1957-1966.
  • 5Drusco A, Nuovo GJ, Zanesi N, et al. MicroRNA profiles discriminate among colon cancer metastasis [J]. PLoS One, 2014, 9:e96670.
  • 6Christensen LL, Holm A, Rantala J, etal. Functional screening identifies miRNAs influencing apoptosis and prolif eration in colorectal cancer [J], PLoS One, 2014, 9:e96767.
  • 7Zhang L, Dong Y, Zhu N, et al. microRNA-139-5p exerts tumor suppressor function by targeting NOTCH1 in colorec- talcaneer[J]. Mol Cancer, 2014, 13:124.
  • 8Fang L1, Li H, Wang L, et al. MicroRNA-17-5p promotes chemotherapeutic drug resistance and tumour metastasis of colorectal cancer by repressing PTEN expression [J]. Onco- target, 2014, 5:2974-2987.
  • 9Tang W, Zhu Y, Gao J, et al. MicroRNA-29a promotes eolorectal cancer metastasis by regulating matrix metallopro- teinase 2 and E-cadherin via KLF4 [J]. Br J Cancer, 2014, 110,450-458.
  • 10Meng F, Henson R, Wehbe-Janek H, et al. MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer[J].Gastroenterology, 2007, 133:647-658.

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二级引证文献7

现代免疫学
2013年 第5期

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