Galectin-3在胚胎着床中作用的研究进展

Research Progress of Galectin-3 Biological Function in Embryo Implantation

Galectin-3是半乳糖凝集素家族中的一员,广泛分布于不同的细胞和组织中。Galectin-3能通过与细胞内、外的不同蛋白间特殊的结合参与细胞黏附、增殖、免疫调节、凋亡和肿瘤的发生、发展等一系列生理、病理过程。而在生殖领域的研究中发现Galectin-3在着床窗口期高表达,以及在此期间激素通过调节Galectin-3及其配体的表达来建立和维持成功的妊娠;另一方面Galectin-3又可调节子宫内膜细胞的增殖和黏附,从而影响胚胎着床的成功。

Galectin-3 as one member of the lectins family is widely spread among different types of cells and tissues. Through specific interactions with a variety of intra and extracellular proteins, Galectin- 3 affects numerous biological processes and seems to be involved in different physiological and patho physiological conditions, such as cell-cell adhesion, proliferation, immune reactions, apoptois and neo- plastic development. The researches in reproduction area found the high expression of Galectin-3 mediated by female hormonal during embryo implantation, which promotes and maintains a successful pregnancy. Meanwhile, Galectin-3 regulates the proliferation and adhesion of endometrial cells to affect embryo implantation.