钙整合素结合蛋白研究进展

Research progress of calcium-and integrin-binding proteins

近年研究表明,钙整合素结合蛋白(CIB)在多种组织广泛表达并参与各种不同的细胞生物学过程。CIB可与许多蛋白发生相互作用,参与DNA损伤修复、细胞周期调节、细胞凋亡、神经系统早期发育、神经元可塑性、神经退行性疾病等病理生理过程,因此对CIB的深入研究将为疾病的治疗提供新的思路。文章对CIB的研究进展进行综述。

Recent researches show that calcium- and integrin-binding proteins （CIB） express in lots of tissues and participate in a wide variety of different cell biological processes. CIB can interact with multitudinous proteins, and may involve in the DNA damage response, cell cycle, cell apoptosis, embryogenesis, neuronal plasticity and neurodegenerative diseases. So in-depth research on CIB may provide new ideas for the treatment of diseases. The research progress of CIB is reviewed in this paper.