二膦酸盐类药物的抗肿瘤作用

Anti-tumor effect of bisphosphonate drugs

二膦酸盐类药物自从被发现具有抑制破骨细胞作用以来,已成为临床上重要的抗骨吸收药物。近年来发现,二膦酸盐类药物也可作用于肿瘤细胞,具有抗肿瘤作用。尤其是与其他抗肿瘤药物的协同作用,使其在临床上能更好地发挥抗肿瘤作用,改善患者的生活质量。该文主要对二膦酸盐类药物的抗肿瘤作用进行综述。

Bisphosphonate drugs have become important drugs have inhibitory effect on osteoclasts. Recently, more and more tumor cells, exhibiting the anti-tumor activity. Especially, the for anti-resorption of bone in clinics since they were found to researches propose that bisphosphonate drugs can also affect synergy effect of bisphosphonate drugs and anti-tumor drugs makes bisphosphonate drugs play a better anti-tumor role in clinics, improving the quality of life of patients. This paper reviews the anti-tumor effect of bisphosphonate drugs.