hMSH2蛋白在喉鳞状细胞癌组织中的表达及意义

Expression and significance of hMSH2 protein in laryngeal squamous cell carcinoma

目的:探讨hMSH2蛋白在喉鳞状细胞癌组织中的表达及意义。方法:采用免疫组织化学法检测喉鳞状细胞癌组织中hMSH2蛋白的表达,并以声带不典型增生组织和正常喉组织作为对照。结果:在喉鳞状细胞癌、声带不典型增生组织和正常喉组织中hMSH2蛋白的阳性率依次为58.8%、73.3%、87.5%,各组间差异有统计学意义(P<0.05);hMSH2蛋白的阳性率与喉癌部位、T分期无明显相关性(P>0.05),而与喉癌的分化程度、淋巴结转移具有相关性(P<0.05)。结论:hMSH2蛋白表达下调可能参与了喉癌早期的发生过程;hMSH2蛋白可能具有抑制喉癌发生发展的作用。

Objective：To study the expression and significance of hMSH2 protein in laryngeal squamous cell carcinoma. Method：The expression of hMSH2 protein were detected by immunohistochemistry SP method in 51 cases of laryngeal squamous cell carcinoma,the control group included 30 cases of atypical hyperplasia tissue of vocal fold and 16 cases of normal laryngeal tissue. Result： The expression rates of hMSH2 in laryngeal squamous cell carcinoma, atypical hyperplasia tissue of vocal fold and normal laryngeal tissue were 58.8% ,73.3% ,87.5% respectively. There was significant difference among them（P〈0.05）. The expression of hMSH2 in laryngeal carcinoma was not associated with location and T stage（P〉0.05）, but the expression was related with metastasis of lymphnode and differentiation level（ P 〈 0. 05）. Conclusion： The deletion of hMSH2 maybe participate the early occurrence of laryngeal carcinoma; hMSH2 protein maybe delay and suppress oncogenesis and development of laryngeal carcinoma.