微小RNA-494在肿瘤发生发展中的作用

Roles of miR-494 in tumors

微小RNA-494（miR-494）参与正常细胞的细胞周期调控、分化和凋亡等过程。近年来研究表明，miR-494的异常表达与肿瘤的发生密切相关，其参与肿瘤细胞的侵袭和转移等过程。miR-494是一种肿瘤抑制基因，也可作为癌基因，其通过多种靶基因、信号通路对肿瘤发生发展进行调控。

MiR494 involves in cell cycle regulation, differentiation and apoptosis processes of normal cells. Recent study shows that abnormal expression of miR-494 is associated with oncogenesis closely, and it participates in the invasion and metastasis of tumor cells and so on. MiR-494 is not only a tumor suppressor gene, but also can be considered as a cancer-promoting gene. MiR-494 can regulate the oncogenesis and devel- opment of the tumor through a variety of target genes and signaling pathways.