摘要
微小RNA-494(miR-494)参与正常细胞的细胞周期调控、分化和凋亡等过程。近年来研究表明,miR-494的异常表达与肿瘤的发生密切相关,其参与肿瘤细胞的侵袭和转移等过程。miR-494是一种肿瘤抑制基因,也可作为癌基因,其通过多种靶基因、信号通路对肿瘤发生发展进行调控。
MiR494 involves in cell cycle regulation, differentiation and apoptosis processes of normal cells. Recent study shows that abnormal expression of miR-494 is associated with oncogenesis closely, and it participates in the invasion and metastasis of tumor cells and so on. MiR-494 is not only a tumor suppressor gene, but also can be considered as a cancer-promoting gene. MiR-494 can regulate the oncogenesis and devel- opment of the tumor through a variety of target genes and signaling pathways.
出处
《国际肿瘤学杂志》
CAS
2013年第10期726-729,共4页
Journal of International Oncology
基金
广东省科技计划项目(20118031800324)