G蛋白调节信号5在肿瘤中的作用

Roles of regulator of G-protein signaling 5 in tumors

G蛋白调节信号5（RGS5）是G蛋白信号调节蛋白（RGS）家族中的一员，负性调节该信号通路的传导。RGS5主要表达在血管周细胞，与血管的发生、发展及成熟密切相关。RGS5基因缺失可引起周细胞成熟和肿瘤血管正常化，此期间联合化疗或免疫治疗可提高疗效，提示RGS5可能成为抗肿瘤治疗的新靶点。RGS5还与肿瘤转移、细胞凋亡有关，可通过诱导细胞凋亡来增加抗肿瘤治疗的效果。

Regulator of G-protein signaling 5 （ RGS5 ） belongs to RGS family, which can negatively regulate the conduction of this signaling pathway. RGS5 mainly expresses in vascular pericyte, and is closely related to the occurrence, development and maturation of the blood vessels, loss of RGS5 results in pericyte maturation, tumor vascular normalization, and these changes can improve the curative effect combined with chemotherapy and immunotherapy, indicating that RGS5 may become a new target of anti-tumor treatment. In addition, RGS5 involves in tumor metastasis and apoptosis, which can improve antineoplastic effect by inducing tumor cells apoptosis.