BRAF基因突变与皮肤黑色素瘤临床病理特征关系的meta分析

Relationship between BRAF mutations and clinicopathological features in cutaneous melanoma： a meta-analysis

目的探讨BRAF突变频率以及该突变与皮肤黑色素瘤（CM）临床病理特征的关系。方法使用Pubmed、Embase、维普、清华同方等数据库检索2013年4月以前相关文献，按纳入排除标准筛选文献，采用Revman5．0软件进行统计分析。结果涉及BRAF突变有9项研究，共1134例患者。CM患者BRAF突变率为47．3％。50岁以上患者BRAF突变OR=2．30，95％CI为1．36～3．91；浅表扩散性黑色素瘤（SSM）BRAF突变OR=2．11，95％CI为1．64～2．7l；病灶在躯干时BRAF基因突变OR=2．35，95％CI为1．71～3．21；浸润深度小于1mm时BRAF突变OR=1．56，95％CI为1．08～2．25。结论BRAF基因突变易发生于年龄50岁以上、SSM、病灶在躯干及浸润深度小于1mm的患者，而与性别无关。

Objective To explore the frequencies of BRAF mutations and the relationship between BRAF mutations and clinicopathological features of cutaneous melanoma （CM）. Methods Pubmed, Embase, VIP, CNKI and other databases were utilized to search the relative articles and literatures were screened accord- ing to inclusion and excluding criteria and the meta-analysis was conducted by RevmanS. 0 software. Results Nine researches about BRAF mutations were enrolled in this study including 1134 patients. BRAF mutation rate of CM was 47.3%. As for patients over 50 years old, the OR of BRAF mutations was 2.30 （95% CI： 1.36- 3.91; the OR of BRAF mutations for superficial spreading melanoma （SSM） was 2. 11 （95% CI： !. 64- 2.71 ） ; the OR of BRAF mutations for lesions in the trunk was 2.35 （95% CI： 1.71-3.21 ） ; the OR of BRAF mutations for invasion depth less than 1 mm was f. 56 （95% CI： 1.08-2.25 ）; Conclusion BRAF mutations are more frequent in patients over 50 years old, in SSM and in patients whose lesions locate in the truck and invasion depth less than 1 mm, but have no relationship with sex.